期刊
ADVANCED MATERIALS
卷 32, 期 30, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202001808
关键词
anticancer vaccines; artificial antigen presentation; cell-membrane-coated nanoparticles; genetic engineering; immunotherapy
类别
资金
- NCI NIH HHS [T32 CA153915, R01 CA200574] Funding Source: Medline
- NIH HHS [5T32CA153915, R01CA200574] Funding Source: Medline
The recent success of immunotherapies has highlighted the power of leveraging the immune system in the fight against cancer. In order for most immune-based therapies to succeed, T cell subsets with the correct tumor-targeting specificities must be mobilized. When such specificities are lacking, providing the immune system with tumor antigen material for processing and presentation is a common strategy for stimulating antigen-specific T cell populations. While straightforward in principle, experience has shown that manipulation of the antigen presentation process can be incredibly complex, necessitating sophisticated strategies that are difficult to translate. Herein, the design of a biomimetic nanoparticle platform is reported that can be used to directly stimulate T cells without the need for professional antigen-presenting cells. The nanoparticles are fabricated using a cell membrane coating derived from cancer cells engineered to express a co-stimulatory marker. Combined with the peptide epitopes naturally presented on the membrane surface, the final formulation contains the necessary signals to promote tumor antigen-specific immune responses, priming T cells that can be used to control tumor growth. The reported approach represents an emerging strategy that can be used to develop multiantigenic, personalized cancer immunotherapies.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据