期刊
ADVANCED MATERIALS
卷 32, 期 36, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.202002246
关键词
biomimetic chemistry; nanocatalytic medicine; parallel catalytic therapy; reactive oxygen species; single-atom catalysts
类别
资金
- National Key Research and Development Program of China [2016YFA0203700]
- National Natural Science Foundation of China [51722211, 21835007, 51672303]
- Program of Shanghai Academic Research Leader [18XD1404300]
The oxidation of intracellular biomolecules by reactive oxygen species (ROS) forms the basis for ROS-based tumor therapy. However, the current therapeutic modalities cannot catalyze H(2)O(2)and O(2)concurrently for ROS generation, thereby leading to unsatisfactory therapeutic efficacy. Herein, it is reported a bioinspired hollow N-doped carbon sphere doped with a single-atom copper species (Cu-HNCS) that can directly catalyze the decomposition of both oxygen and hydrogen peroxide to ROS, namely superoxide ion (O-2 center dot(-)) and the hydroxyl radical (center dot OH), respectively, in an acidic tumor microenvironment for the oxidation of intracellular biomolecules without external energy input, thus resulting in an enhanced tumor growth inhibitory effect. Notably, the Fenton reaction turnover frequency of Cu species in Cu-HNCS is approximate to 5000 times higher than that of Fe in commercial Fe(3)O(4)nanoparticles. Experimental results and density functional theory calculations reveal that the high catalytic activity of Cu-HNCS originates from the single-atom copper, and the calculation predicts a next-generation Fenton catalyst. This work provides an effective paradigm of tumor parallel catalytic therapy for considerably enhanced therapeutic efficacy.
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