期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 38, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202004599
关键词
biomaterials; functional interfaces; hybrid materials; hydrogel; radical functionalization; soft matter
类别
资金
- Australian Research Council (ARC) [DP190103507, FL190100216]
Combinations of hydrogels and solids provide high level functionality for devices such as tissue engineering scaffolds and soft machines. However, the weak bonding between hydrogels and solids hampers functionality. Here, a versatile strategy to develop mechanically robust solid-hydrogel hybrid materials using surface embedded radicals generated through plasma immersion ion implantation (PIII) of polymeric surfaces is reported. Evidence is provided that the reactive radicals play a dual role: inducing surface-initiated, spontaneous polymerization of hydrogels; and binding the hydrogels to the surfaces. Acrylamide and silk hydrogels are formed and covalently attached through spontaneous reactions with the radicals on PIII activated polymer surfaces without cross-linking agents or initiators. The hydrogel amount increases with incubation time, monomer concentration, and temperature. Stability tests indicate that 95% of the hydrogel is retained even after 4 months in PBS solution. T-peel tests show that failure occurs at the tape-hydrogel interface and the hydrogel-PIII-treated PTFE interfacial adhesion strength is over 300 N m(-1). Cell assays show no adhesion to the as-synthesized hydrogels; however, hydrogels synthesized with fibronectin enable cell adhesion and spreading. These results show that polymers functionalized with surface-embedded radicals provide excellent solid platforms for the generation of robust solid-hydrogel hybrid structures for biomedical applications.
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