期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 159, 期 -, 页码 377-390出版社
ELSEVIER
DOI: 10.1016/j.addr.2020.08.003
关键词
Biocompatible nanoparticles; Chemotherapy; Chylomicrons; Drug delivery; High-density lipoproteins; Low-density lipoproteins; Lymphatic transport; Purification; Synthetic lipoproteins; Very low-density lipoproteins
资金
- Mayo Clinic Center for Regenerative Medicine Florida Award
- Mayo Clinic Florida Focused Research Team Program
- National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States [R21AI152318]
Lipoproteins (LPs) are circulating heterogeneous nanoparticles produced by the liver and intestines. LPs play a major role in the transport of dietary and endogenous lipids to target cells through cell membrane receptors or cell surface-bound lipoprotein lipase. The stability, biocompatibility, and selective transport of LPs make them promising delivery vehicles for various therapeutic and imaging agents. This review discusses isolation, manufacturing, and drug loading techniques used for LP-based drug delivery, as well as recent applications for diagnosis and treatment of cancer, atherosclerosis, and other life-threatening diseases. (C) 2020 Elsevier B.V. All rights reserved.
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