期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 154, 期 -, 页码 227-235出版社
ELSEVIER
DOI: 10.1016/j.addr.2020.06.016
关键词
Liposomes; Weak electric current; Iontophoresis; Noninvasive; Transdermal delivery; Endocytosis
资金
- JSPS KAKENHI [18F18097, 17H03976]
- Tokushima University
- Grants-in-Aid for Scientific Research [18F18097, 17H03976] Funding Source: KAKEN
Noninvasive transdermal drug delivery (NTDD) offers an exciting new method of administration relative to conventional routes, but is associated with some challenges. Liposomes are capable of encapsulating transdermally-unfavorable drugs. However, the horny layer of skin is a significant barrier that limits efficient transdermal delivery of liposomes. Iontophoresis using weak electric current (WEC) represents a NTDD technology. WEC treatment of liposomes applied to the skin surface improves transdermal penetration of encapsulated drugs by cooperative effects. In this review, we provide an overview of the application of WEC/liposomes for transdermal delivery of macromolecules and low molecular weight drugs. We compare the transdermal delivery and therapeutic efficiency of the combined system with conventional routes of administration and their individual use. We discuss a novel perspective on the mechanism of WEC-mediated transdermal delivery of liposomes, which suggests that WEC activates the intracellular signaling pathway for transdermal permeation and induces unique endocytosis in skin cells. (C) 2020 Elsevier B.V. All rights reserved.
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