期刊
CHINESE CHEMICAL LETTERS
卷 27, 期 6, 页码 957-960出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2016.02.008
关键词
Harziane diterpenoids; Trichoderma sp Xy24; Endophytic fungus; Mangrove plant; Cytotoxic activity
资金
- Science AMP
- Technology Project of Guangdong Province [2011A080403020]
Two new harziane diterpenoids, named (9R,10R)-dihydro-harzianone (1) and harzianelactone (2), were isolated from the endophytic fungus Trichoderrna sp. Xy24 by using various column chromatography techniques. Their structures were determined on the basis of extensive spectroscopic (HR-ESI-MS, 1D NMR, 2D NMR and CD) analyses. Among them, 1 was the reductive product of harzianone and 2 was the Baeyer-Villiger monooxygenase catalyzed oxidation product of harzianone. Compound 1 exhibited cytotoxic activity against HeLa and MCF-7 cell lines with IC50 values of 30.1 mu mol/L and 30.7 mu mol/L, respectively. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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