期刊
ACS NANO
卷 14, 期 8, 页码 10001-10017出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c03094
关键词
stimuli response; nanoradiosensitization; intratumoral biodegradation and disassembly; enhanced tumor penetration; synergistic therapies
类别
资金
- National Basic Research Programs of China [2016YFA0201600]
- National Natural Science Foundation of China [51772293, U1932112, 51772292, 11621505, 51822207]
- Beijing Natural Science Foundation [2202064]
- China Postdoctoral Science Foundation [2019M660794]
- CAS Key Laboratory of Nano-Bio Interface [20NBI01]
Development of an efficient nanoradiosensitization system that enhances the radiation doses in cancer cells to sensitize radiotherapy (RT) while sparing normal tissues is highly desirable. Here, we construct a tumor microenvironment (TME)-responsive disassembled small-on-large molybdenum disulfide/hafnium dioxide (MoS2/HfO2) dextran (M/H-D) nanoradiosensitizer. The M/H-D can degrade and release the HfO2 nanoparticles (NPs) in TME to enhance tumor penetration of the HfO2 NPs upon near-infrared (NIR) exposure, which can solve the bottleneck of insufficient internalization of the HfO2, NPs. Simultaneously, the NIR photothermal therapy increased peroxidase-like catalytic efficiency of the M/H-D nanoradiosensitizer in TME, which selectively catalyzed intratumorally overexpressed H2O2 into highly oxidized hydroxyl radicals (center dot OH). The heat induced by PTT also relieved the intratumoral hypoxia to sensitize RT. Consequently, this TME-responsive precise nanoradiosensitization achieved improved irradiation effectiveness, potent oxygenation in tumor, and efficient suppression to tumor, which can be real-time monitored by computed tomography and photoacoustic imaging.
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