期刊
ACS NANO
卷 14, 期 11, 页码 14635-14645出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c03754
关键词
acoustics; acoustofluidics; nanoparticle manipulation; cell pattern; acoustic tweezers
类别
资金
- National Institutes of Health [R01GM132603, R01GM135486, UG3TR002978, R33CA223908, R01GM127714, R01HD086325]
- United States Army Medical Research Acquisition Activity [W81XWH-18-1-0242]
- National Science Foundation [ECCS-1807601]
Acoustic-based techniques can manipulate particles in a label-free, contact-free, and biocompatible manner. However, most previous work in acoustic manipulation has been constrained by axisymmetric patterns of pressure nodes and antinodes. Acoustic holography is an emerging technique that offers the potential to generate arbitrary pressure distributions which can be applied to particle manipulation with higher degrees of freedom. However, since current acoustic holography techniques rely on acoustic radiation forces, which decrease dramatically when the target particle size decreases, they have difficulty manipulating particles in the micro/nanoscale. Here, we introduce a holography technique that leverages both an arbitrary acoustic field and controllable fluid motion to offer an effective approach for manipulating micro/nano particles. Our approach, termed acoustofluidic holography (AFH), can manipulate a variety of materials, including cells, polymers, and metals, across sizes ranging from hundreds of micrometers to tens of nanometers.
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