期刊
CHINESE CHEMICAL LETTERS
卷 27, 期 1, 页码 16-20出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.cclet.2015.08.012
关键词
Bis(indolyl)methanes; Microwave irradiation; Antibacterial activity; Anti-inflammatory activity
资金
- University Grants Commission (UGC), New Delhi, India [42-281/2013 (SR)]
A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac, respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity. Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound. (C) 2015 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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