期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 29, 页码 32372-32387出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07503
关键词
chemo-photodynamic therapy; upconversion nanoparticles; ROS-responsive micelles; immunogenic cell death; tumor metastasis
资金
- National key Research and Development projects intergovernmental cooperation in science and technology of China [2018YFE0126900]
- Joint Institute of Lishui Hospital
A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse and metastasis. During this research, multifunctional upconversion nanoparticles (UCNPs) coated by ROS-responsive micelles are prepared for tumor targeting and near-infrared (NIR)-triggered photodynamic therapy (PDT)-combined synergistic effect of chemotherapy. Moreover, both PDT and chemotherapy agents could activate antitumor immunity via inducing immunogenic cell death with CD8(+) and CD4(+)T cells infiltrating in tumors. Through the experiments, intravenous administration of multifunctional nanocarriers with noninvasive NIR irradiation destroys the orthotopic tumors and efficiently suppresses lung metastasis in a metastatic triple-negative breast cancer model by cascade-amplifying chemo-PDT and systemic antitumor immunity. In conclusion, this study provides prospective chemo-PDT with inspired antitumor immunity for metastatic cancer treatment.
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