Metal complexes of anthranilic acid derivatives: A new class of noncompetitive α-glucosidase inhibitors

Metal complexes of anthranilic acid derivatives that constitute a novel class of non-sugar-type alpha-glucosidase inhibitors were synthesized and assessed in vitro for inhibitory activity. All of the Ag(I) complexes (9-16) inhibited alpha-glucosidase at the nanomolar scale, while 3,5-dichloroanthranilic acid silver(I) (9) was the most potent (IC50=3.21 nmol/L). Analysis of the kinetics of enzyme inhibition indicated that the mechanism of the newly prepared silver complexes was noncompetitive. The structure-activity relationships were also analyzed, and they are discussed in this report. (C) 2016 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.