期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 35, 页码 38906-38917出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c08389
关键词
yolk-shell nanostructure; mesoporous MnO2 Shell; tumor microenvironment; multimodal imaging; chemo-photodynamic therapy
资金
- National Key R&D Program of China [2017YFA0205100]
- National Natural Science Foundation of China [21671043, 21877013, 81702177]
- Shanghai Rising Stars of Medical Talent Youth Development Program [[2020]087]
Manganese dioxide (MnO2) nanostructures have aroused great interest among analytical and biological medicine researchers as a unique type of tumor microenvironment (TME)-responsive nanomaterial. However, reliable approaches for synthesizing yolk-shell nanostructures (YSNs) with mesoporous MnO2 shell still remain exciting challenges. Herein, a YSN (size, similar to 75 nm) containing a mesoporous MnO2 shell and Er3+-doped upconversion/downconversion nanoparticle (UCNP) core with a large cavity is demonstrated for the first time. This nanostructure not only integrates diverse functional components including MnO2, UCNPs, and YSNs into one system but also endows a size-controllable hollow cavity and thickness-tunable MnO2 layers, which can load various guest molecules like photosensitizers, methylene blue (MB), and the anticancer drugs doxorubicin (DOX). NIR-II fluorescence and photoacoustic (PA) imaging from UCNP and MB, respectively, can monitor the enrichment of the nanomaterials in the tumors for guiding chemo-photodynamic therapy (PDT) in vivo. In the TME, degradation of the mMnO(2) shell by H2O2 and GSH not only generates Mn2+ for tumor-specific T-1-MR imaging but also releases O-2 and drugs for tumor-specific treatment. The result confirmed that imaging-guided enhanced chemo-PDT combination therapy that benefited from the unique structural features of YSNs could substantially improve the therapeutic effectiveness toward malignant tumors compared to monotherapy.
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