期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 26, 页码 29066-29073出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c06793
关键词
photoelectrochemical immunoassay; carcinoembryonic antigen; ascorbic acid; V2O5 nanosheets; CdS quantum dots
资金
- National Natural Science Foundation of China [21705045, 21675050]
- Natural Science Foundation of Hunan Province [2019JJ50385, 2018JJ2252]
- Science and Technology Innovation Project of Hunan Province [2018RS3062]
- Science and Technology Project of Changsha [KQ1905028]
We report here CdS quantum-dots (QDs)-decorated V2O5 nanosheets as high-performance and chemically etchable photoelectric active materials for constructing a photoelectrochemical (PEC) immunoassay platform. CdS QDs-decorated V2O5 nanosheets as new photoelectric materials can show superior photocurrent to V2O5 nanosheets and CdS QDs under visible-light irradiation because of the promoted photogenerated electron-hole separation and the increased visible-light absorption. V2O5 nanosheets can be etched by ascorbic acid (AA) because of the reduction of V2O5 to V4+, and the photocurrent of CdS/V2O5-nanocomposite-modified indium tin oxide electrode decreases significantly after being etched by AA. Inspired by this phenomenon, a PEC immunoassay platform is constructed for carcinoembryonic antigen (CEA) detection by using CdS/V2O5 nanocomposite as the photoelectric material and AA-encapsulated liposome immunonanocapsules as labels. The linear detection range for detecting CEA is from 0.5 pg mL(-1) to 1 ng mL(-1), with a limit of detection of 0.1 pg mL(-1). The proposed method also shows good selectivity, excellent reproducibility, and satisfactory recovery in detection of CEA in human serum samples. We believe that this work will lay the foundation for the future development of V2O5-based materials for PEC analysis, and also provide a reasonable design and implementation for the development of PEC immunoassay.
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