期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 30, 页码 33483-33491出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07419
关键词
hyperthermia; high frequency; theranostic; iron oxide nanoparticle; multigranule nanocluster; polyethylene glycol
资金
- National Research Foundation of Korea (NRF) - Ministry of Science and ICT [2019R1A2C3006587]
- Basic Science Research Program through the Research Foundation of Korea (NRF) - Ministry of Education [2019R1I1A1A01062020]
- KU-KIST Graduate School of Converging Science and Technology (Korea University)
- Institute for Basic Science (IBS) Center for Neuroscience Imaging Research [IBS-R015-D1]
- Intramural Research Program of KIST
- National Research Foundation of Korea [2E30350, 2019R1I1A1A01062020] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The development of heat-generating magnetic nanostructures is critical for the effective management of tumors using magnetic hyperthermia. Herein, we demonstrate that polyethylene glycol (PEG)-coated iron oxide (magnetite, Fe3O4) multigranule nanoclusters (PEG-MGNCs) can enhance the efficiency of hyperthermia-based tumor suppression in vitro and in vivo. MGNCs consisting of granules (crystallites) measuring 22.9 nm in diameter were prepared via the hydrothermal polyol method, followed by the surface modification of MGNCs with PEG-dopamine. The freshly prepared PEG-MGNCs exhibit 145.9 +/- 10.2 nm diameter on average under aqueous conditions. The three-dimensional structures of PEG-MGNCs enhance the hyperthermic efficacy compared with PEGylated single iron-oxide nanoparticles (NPs), resulting in severe heat damage to tumor cells in vitro. In the SCC7 tumor-bearing mice, near-infrared fluorescence dye (Cy5.5)-labeled PEG-MGNCs are successfully accumulated in the tumor tissues because of NP-derived enhanced permeation and retention effect. Finally, the tumor growth is significantly suppressed in PEG-MGNC-treated mice after two-times heat generation by using a longitudinal solenoid, which can generate an alternating magnetic field under high-frequency (19.5 kA/m, 389 kHz) induction. This study shows for the first time that the PEG-MGNCs greatly enhance the hyperthermic efficacy of tumor treatment both in vitro and in vivo.
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