期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 37, 页码 41088-41095出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c11735
关键词
carbon dots; reactive oxygen species; macrophage; antioxidant; antioxidant therapy
资金
- National MCF Energy RD Program [2018YFE0306105]
- Innovative Research Group Project of the National Natural Science Foundation of China [51821002]
- National Natural Science Foundation of China [51725204, 21771132, 51972216, 52041202]
- Natural Science Foundation of Jiangsu Province [BK20190041]
- Collaborative Innovation Center of Suzhou Nano Science Technology
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- 111 Project
Reactive oxygen species (ROSs), acting as functionalized molecules in intracellular enzyme reactions and intercellular communication of immune response, play vital roles in biological metabolism. However, the inevitably excessive ROS-induced oxidative stress is harmful for organ tissue, causing unexpected local anaphylaxis or inflammation. Here, we demonstrate carbon dots (CDs), made of citric acid and glutathione via one-step hydrothermal method, as a highly efficient intracellular ROS scavenger for alleviating the lipopolysaccharide (LPS)-induced inflammation in macrophage. These CDs have broad-spectrum antioxidant properties and the total antioxidant activity exceeds 51.6% higher than that of the precursor, namely, glutathione, in the same mass concentration. Moreover, their antioxidative performance in macrophage inflammation induced by LPS was investigated, and it was found that CDs can efficiently remove up to 98% of intracellular ROS, notably inhibiting nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappa B) signaling pathway, and decrease the expression level of inflammatory factor IL-12. Our results suggested that CDs can serve as a highly efficient intracellular ROS scavenger and could be employed to cope with oxidative stress-induced diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据