期刊
BLOOD
卷 126, 期 22, 页码 2443-2451出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2015-07-533588
关键词
-
类别
资金
- National Institutes of Health (NIH)
- National Institute of Diabetes and Kidney Diseases [DK081843]
- National Cancer Institute [CA166280]
- National Institute of Allergy and Infectious Diseases [AI107376]
- National Institute on Aging [AGO46293]
- National Heart, Lung and Blood Institute [HL60772]
The bone marrow microenvironment contains a heterogeneous population of stromal cells organized into niches that support hematopoietic stem cells (HSCs) and other lineage-committed hematopoietic progenitors. The stem cell niche generates signals that regulate HSC self-renewal, quiescence, and differentiation. Here, we review recent studies that highlight the heterogeneity of the stromal cells that comprise stem cell niches and the complexity of the signals that they generate. We highlight emerging data that stem cell niches in the bone marrow are not static but instead are responsive to environmental stimuli. Finally, we review recent data showing that hematopoietic niches are altered in certain hematopoietic malignancies, and we discuss how these alterations might contribute to disease pathogenesis.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据