期刊
JOURNAL OF MARINE SCIENCE AND ENGINEERING
卷 8, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jmse8040261
关键词
echinoderm; breast cancer; cytotoxicity
资金
- University of Palermo (Italy)
- Fondo Finalizzato alla Ricerca (FFR)
Triple-negative breast cancer (TNBC) is a highly malignant tumor histotype which lacks effective targeted therapies, thereby being considered as the most aggressive form of breast carcinoma. To identify novel compounds which could counteract TNBC cell growth, we explored the in vitro effects of crude extracts and Arbacia lixula on TNBC MDA-MB231 cells. We examined cell viability, cycle distribution, apoptotic/autophagic activity, and mitochondrial polarization/cell redox status. Here, we report the first data demonstrating an anti-TNBC effect by A. lixula-derived coelomic fluid extracts. Thus, identification of the water-soluble bioactive component(s) contained in the extracts deserve(s) further investigation aimed to devise novel promising prevention and/or treatment agents effective against highly malignant breast tumors.
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