期刊
ACS OMEGA
卷 5, 期 13, 页码 7481-7487出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsomega.0c00225
关键词
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资金
- CONICET
- CONICET PIP [20150524]
- Agencia Nacional de Promocion Cientifica y Tecnologica (ANPCyT, PICT) [2015-2259]
- ANPCyT (PICT) [2014-0408, 2017-2694]
- Agencia Santafesina de Ciencia, Tecnologia e Innovacion (ASACTEI) [AC -2015-00005]
- Universidad Nacional de Rosario (UNR) [BIO580]
The natural product zanthosimuline and its 18 analogues were easily prepared from simple starting materials and evaluated in vitro against postharvest fruit fungal pathogens. The panel included Penicillium digitatum, Botrytis cinerea, Monilinia fructicola, and Rhizopus stolonifer; all of them causing relevant economic losses worldwide. The minimum inhibitory concentrations and minimum fungicidal concentrations of each compound were determined, and the main structure-activity relationships were established. The biological activity observed was strongly increased by maintaining the prenyl side chain of zanthosimuline in an N-demethylated derivative. In addition, the compound that is the most active in the in vitro evaluation was tested in freshly harvested peaches exhibiting a promising brown rot control profile, comparable to the commercial agent carbendazim but demonstrating less toxicity against human liver cell lines.
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