期刊
METABOLITES
卷 10, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/metabo10040147
关键词
lipolysis; adipose tissue; triacylglycerol; lipase; fatty acid; lipid biochemistry; lipid droplets
资金
- FWF [P28882-B21, P31638-B34, SFB F73]
The catabolism of intracellular triacylglycerols (TAGs) involves the activity of cytoplasmic and lysosomal enzymes. Cytoplasmic TAG hydrolysis, commonly termed lipolysis, is catalyzed by the sequential action of three major hydrolases, namely adipose triglyceride lipase, hormone-sensitive lipase, and monoacylglycerol lipase. All three enzymes interact with numerous protein binding partners that modulate their activity, cellular localization, or stability. Deficiencies of these auxiliary proteins can lead to derangements in neutral lipid metabolism and energy homeostasis. In this review, we summarize the composition and the dynamics of the complex lipolytic machinery we like to call lipolysome.
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