期刊
REGENERATIVE BIOMATERIALS
卷 7, 期 4, 页码 349-358出版社
OXFORD UNIV PRESS
DOI: 10.1093/rb/rbaa019
关键词
atherosclerosis; nanoparticle; cell membrane; extracellular vesicle
资金
- Open Fund for Key Laboratory of Biorheological Science and Technology, Ministry of Education [CQKLBST-2019-010]
- Project of Tutorial System of Medical Undergraduate in Lab Teaching & Management Center in Chongqing Medical University [LTMCMTS201905]
- Undergraduate Scientific Research and Innovation Laboratory Project of Chongqing Medical University [201965]
- Chongqing Engineering Laboratory in Vascular Implants
- Public Experiment Centre of State Bioindustrial Base (Chongqing)
- Laboratory of Tissue and Cell Biology
Atherosclerosis is a key mechanism underlying the pathogenesis of cardiovascular disease, which is associated with high morbidity and mortality. In the field of precision medicine for the treatment of atherosclerosis, nanoparticle (NP)-mediated drug delivery systems have great potential, owing to their ability to release treatment locally. Cell-derived biomimetic NPs have attracted extensive attention at present due to their excellent targeting to atherosclerotic inflammatory sites, low immunogenicity and long blood circulation time. Here, we review the utility of cell-derived biomimetic NPs, including whole cells, cell membranes and extracellular vesicles, in the treatment of atherosclerosis.
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