期刊
PATHOGENS
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/pathogens9050403
关键词
human papillomavirus; cervical cancer; head and neck cancer; oropharyngeal cancer; estrogen; estrogen receptor
类别
资金
- National Cancer Institute [P30 CA016059]
High risk-human papillomaviruses (HPVs) are known carcinogens. Numerous reports have linked the steroid hormone estrogen, and the expression of estrogen receptors (ERs), to HPV-related cancers, although the exact nature of the interactions remains to be fully elucidated. Here we will focus on estrogen signaling and describe both pro and potentially anti-cancer effects of this hormone in HPV-positive cancers. This review will summarize: (1) cell culture-related evidence, (2) animal model evidence, and (3) clinical evidence demonstrating an interaction between estrogen and HPV-positive cancers. This comprehensive review provides insights into the potential relationship between estrogen and HPV. We suggest that estrogen may provide a potential therapeutic for HPV-related cancers, however additional studies are necessary.
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