期刊
ANNALS OF TRANSLATIONAL MEDICINE
卷 8, 期 5, 页码 -出版社
AME PUBL CO
DOI: 10.21037/atm.2020.01.18
关键词
Bombyx mori; fibroblast growth factor 21 (FGF21); lifespan; oxidation resistance; stress tolerance
资金
- National Natural Science Foundation of China [31830094, 31902215]
- Hi-Tech Research and Development 863 Program of China [2013AA102507]
- Fundamental Research Funds for the Central Universities in China [XDJK2019C014]
- Chongqing Special Postdoctoral Science Foundation [XmT2018058]
- China Agriculture Research System [CARS-18ZJ0102]
Background: Fibroblast growth factor 21 (FGF21), an FGF family member, is an atypical hormone and pro-longevity factor. Methods: To better understand of the effects of exogenous administration of FGF21 on lifespan and stress tolerance, and the underlying molecular basis, we used the silkworm, Bombyx mori, as an experimental animal model to evaluate FGF21's pharmaceutical effects. Results: Lifespan was significantly prolonged in female silkworms with FGF21 replenishment, whereas no effect was observed in the male silkworms. FGF21 replenishment also significantly improved the activity of antioxidant systems such as glutathione-S-transferase (GST) and superoxide dismutase (SOD) and significantly decreased malondialdehyde (MDA) content. Moreover, FGF21 was found to play a critical role in enhancing stress resistance, including ultraviolet (UV) irradiation tolerance and thermotolerance. Furthermore, AMPK, FoxO, and sirtuins were activated by FGF21 and may be responsible for the prolonged lifespan and enhanced antioxidant activity observed in silkworms. Conclusions: Collectively, the results suggest the molecular pathways underlying of FGF21-induced longevity and stress tolerance, and support the use of silkworms as a promising experimental animal model for evaluating the pharmaceutical effects of small molecules.
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