期刊
FLUIDS AND BARRIERS OF THE CNS
卷 17, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12987-020-00196-2
关键词
Choroid plexus; Blood-cerebrospinal fluid barrier; Inflammatory diseases; Neurodegenerative disease; Autoimmune disease; Stroke; Carcinoma
资金
- Operational Programme Research, Development and Education-Project Postdoc@MUNI [CZ.02.2.69/0.0/0.0/16 _027/0008360]
- Masaryk University [MUNI/A/1086/2018, MUNI/A/0975/2019]
- Faculty of Medicine, Masaryk University [ROZV/23/LF14/2019]
The choroid plexus (CP) forming the blood-cerebrospinal fluid (B-CSF) barrier is among the least studied structures of the central nervous system (CNS) despite its clinical importance. The CP is an epithelio-endothelial convolute comprising a highly vascularized stroma with fenestrated capillaries and a continuous lining of epithelial cells joined by apical tight junctions (TJs) that are crucial in forming the B-CSF barrier. Integrity of the CP is critical for maintaining brain homeostasis and B-CSF barrier permeability. Recent experimental and clinical research has uncovered the significance of the CP in the pathophysiology of various diseases affecting the CNS. The CP is involved in penetration of various pathogens into the CNS, as well as the development of neurodegenerative (e.g., Alzheimer ' s disease) and autoimmune diseases (e.g., multiple sclerosis). Moreover, the CP was shown to be important for restoring brain homeostasis following stroke and trauma. In addition, new diagnostic methods and treatment of CP papilloma and carcinoma have recently been developed. This review describes and summarizes the current state of knowledge with regard to the roles of the CP and B-CSF barrier in the pathophysiology of various types of CNS diseases and sets up the foundation for further avenues of research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据