期刊
MICROORGANISMS
卷 8, 期 6, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms8060809
关键词
Climacostomum virens; secondary metabolites; predator-prey interactions; resorcinolic lipids; ciliates; natural products
类别
资金
- University of Macerata
The review highlights the main results of two decades of research on climacostol (5-[(2Z)-non-2-en-1-yl]benzene-1,3-diol), the resorcinolic lipid produced and used by the ciliated protozoanClimacostomum virensfor chemical defense against a wide range of predators, and to assist its carnivorous feeding. After the first studies on the physiological function of climacostol, the compound and some analogues were chemically synthesized, thus allowing us to explore both its effect on different prokaryotic and eukaryotic biological systems, and the role of its relevant structural traits. In particular, the results obtained in the last 10 years indicate climacostol is an effective antimicrobial and anticancer agent, bringing new clues to the attempt to design and synthesize additional novel analogues that can increase or optimize its pharmacological properties.
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