期刊
MICROORGANISMS
卷 8, 期 3, 页码 -出版社
MDPI
DOI: 10.3390/microorganisms8030425
关键词
quorum sensing; microbial resistance; biofilm; quorum quenching
类别
资金
- National Natural Science Foundation of China [31972166]
- Graduate Innovative Fund ofWuhan Institute of Technology [CX2019195]
Quorum sensing is a cell-to-cell communication system that exists widely in the microbiome and is related to cell density. The high-density colony population can generate a sufficient number of small molecule signals, activate a variety of downstream cellular processes including virulence and drug resistance mechanisms, tolerate antibiotics, and harm the host. This article gives a general introduction to the current research status of microbial quorum-sensing systems, focuses on the role of quorum-sensing systems in regulating microbial resistance mechanisms, such as drug efflux pump and microbial biofilm formation regulation, and discusses a new strategy for the treatment of drug-resistant bacteria proposed by using quorum quenching to prevent microbial resistance.
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