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Systematic review and meta-analysis of mouse models of diabetes-associated ulcers

期刊

出版社

BMJ PUBLISHING GROUP
DOI: 10.1136/bmjdrc-2019-000982

关键词

transgenic and knockout mice; meta-analysis; ulcer(s); laboratory research in diabetes

资金

  1. James Cook University's Strategic Research Intent Fund
  2. National Health and Medical Research Council (NHMRC) Practitioner Fellowship [1117061]
  3. Queensland Government Senior Clinical Research Fellowship (SCRF)

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Mouse models are frequently used to study diabetes-associated ulcers, however, whether these models accurately simulate impaired wound healing has not been thoroughly investigated. This systematic review aimed to determine whether wound healing is impaired in mouse models of diabetes and assess the quality of the past research. A systematic literature search was performed of publicly available databases to identify original articles examining wound healing in mouse models of diabetes. A meta-analysis was performed to examine the effect of diabetes on wound healing rate using random effect models. A meta-regression was performed to examine the effect of diabetes duration on wound healing impairment. The quality of the included studies was also assessed using two newly developed tools. 77 studies using eight different models of diabetes within 678 non-diabetic and 720 diabetic mice were included. Meta-analysis showed that wound healing was impaired in all eight models. Meta-regression suggested that longer duration of diabetes prior to wound induction was correlated with greater degree of wound healing impairment. Pairwise comparisons suggested that non-obese diabetic mice exhibited more severe wound healing impairment compared withdb/dbmice, streptozotocin-induced diabetic mice or high-fat fed mice at an intermediate stage of wound healing (p<0.01). Quality assessment suggested that the prior research frequently lacked incorporation of key clinically relevant characteristics. This systematic review suggested that impaired wound healing can be simulated in many different mouse models of diabetes but these require further refinement to become more clinically relevant.

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