相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。R-Loops as Cellular Regulators and Genomic Threats
Madzia P. Crossley et al.
MOLECULAR CELL (2019)
BRCA1 Haploinsufficiency Is Masked by RNF168-Mediated Chromatin Ubiquitylation
Dali Zong et al.
MOLECULAR CELL (2019)
53BP1 nuclear bodies enforce replication timing at under-replicated DNA to limit heritable DNA damage
Julian Spies et al.
NATURE CELL BIOLOGY (2019)
Phasor histone FLIM-FRET microscopy quantifies spatiotemporal rearrangement of chromatin architecture during the DNA damage response
Jieqiong Lou et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
Multicomponent assemblies in DNA-double-strand break repair by NHEJ
Ales Hnizda et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Replication-Coupled DNA Repair
David Cortez
MOLECULAR CELL (2019)
Isomerization of BRCA1-BARD1 promotes replication fork protection
Manuel Daza-Martin et al.
NATURE (2019)
DNA double-strand break repair-pathway choice in somatic mammalian cells
Ralph Scully et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)
Targeting the cell cycle in head and neck cancer by Chk1 inhibition: a novel concept of bimodal cell death
Anne M. van Harten et al.
ONCOGENESIS (2019)
Preparation for DNA replication: the key to a successful S phase
Juanita C. Limas et al.
FEBS LETTERS (2019)
Mechanism of head-to-head MCM double-hexamer formation revealed by cryo-EM
Thomas C. R. Miller et al.
NATURE (2019)
Stabilization of chromatin topology safeguards genome integrity
Fena Ochs et al.
NATURE (2019)
Mild replication stress causes chromosome mis-segregation via premature centriole disengagement
Therese Wilhelm et al.
NATURE COMMUNICATIONS (2019)
Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection
V. Pragathi Masamsetti et al.
NATURE COMMUNICATIONS (2019)
Tetraploidy causes chromosomal instability in acentriolar mouse embryos
Lia Mara Gomes Paim et al.
NATURE COMMUNICATIONS (2019)
Mechanisms of replication origin licensing: a structural perspective
Franziska Bleichert
CURRENT OPINION IN STRUCTURAL BIOLOGY (2019)
Mouse Genome Database (MGD) 2019
Carol J. Bult et al.
NUCLEIC ACIDS RESEARCH (2019)
The broken cycle: E2F dysfunction in cancer
Lindsey N. Kent et al.
NATURE REVIEWS CANCER (2019)
Deciphering p53 signaling in tumor suppression
Stephano S. Mello et al.
CURRENT OPINION IN CELL BIOLOGY (2018)
Telomere Loop Dynamics in Chromosome End Protection
David Van Ly et al.
MOLECULAR CELL (2018)
Self-assembly of embryonic and two extra- embryonic stem cell types into gastrulating embryo-like structures
Berna Sozen et al.
NATURE CELL BIOLOGY (2018)
RPA and RAD51: fork reversal, fork protection, and genome stability
Kamakoti P. Bhat et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis
Zhongcheng Zhou et al.
NUCLEIC ACIDS RESEARCH (2018)
High Basal Levels of gamma H2AX in Human Induced Pluripotent Stem Cells Are Linked to Replication-Associated DNA Damage and Repair
Haritha Vallabhaneni et al.
STEM CELLS (2018)
Break-Induced Replication: The Where, The Why, and The How
J. Kramara et al.
TRENDS IN GENETICS (2018)
RPA and RAD51: fork reversal, fork protection, and genome stability
Kamakoti P. Bhat et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2018)
Loss of Sfpq Causes Long-Gene Transcriptopathy in the Brain
Akihide Takeuchi et al.
CELL REPORTS (2018)
Preserving replication fork integrity and competence via the homologous recombination pathway
Anissia Ait Saada et al.
DNA REPAIR (2018)
A unified view of spatio-temporal control of mitotic entry: Polo kinase as the key
Lionel Pintard et al.
OPEN BIOLOGY (2018)
Mouse gastrulation: Attributes of transcription factor regulatory network for epiblast patterning
Guizhong Cui et al.
DEVELOPMENT GROWTH & DIFFERENTIATION (2018)
The Protective Role of Dormant Origins in Response to Replicative Stress
Lilas Courtot et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2018)
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress
Sara Przetocka et al.
MOLECULAR CELL (2018)
Mouse embryonic stem cells have increased capacity for replication fork restart driven by the specific Filia-Floped protein complex
Bo Zhao et al.
CELL RESEARCH (2018)
Cycling to Meet Fate: Connecting Pluripotency to the Cell Cycle
Lamuk Zaveri et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2018)
Coupling of Homologous Recombination and the Checkpoint by ATR
Remi Buisson et al.
MOLECULAR CELL (2017)
Replication Fork Reversal: Players and Guardians
Annabel Quinet et al.
MOLECULAR CELL (2017)
Restoration of Replication Fork Stability in BRCA1-and BRCA2-Deficient Cells by Inactivation of SNF2-Family Fork Remodelers
Angelo Taglialatela et al.
MOLECULAR CELL (2017)
DNA mismatch repair and its many roles in eukaryotic cells
Dekang Liu et al.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH (2017)
The control of DNA repair by the cell cycle
Nicole Hustedt et al.
NATURE CELL BIOLOGY (2017)
The essential kinase ATR: ensuring faithful duplication of a challenging genome
Joshua C. Saldivar et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
Non-homologous DNA end joining and alternative pathways to double-strand break repair
Howard H. Y. Chang et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
The multifaceted roles of PARP1 in DNA repair and chromatin remodelling
Arnab Ray Chaudhuri et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2017)
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Pedro A. Mateos-Gomez et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
The role of poly ADP-ribosylation in the first wave of DNA damage response
Chao Liu et al.
NUCLEIC ACIDS RESEARCH (2017)
Shortage of dNTPs underlies altered replication dynamics and DNA breakage in the absence of the APC/C cofactor Cdh1
J. Garzon et al.
ONCOGENE (2017)
The INO80 remodeller in transcription, replication and repair
Jerome Poli et al.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2017)
DNA damage tolerance in hematopoietic stem and progenitor cells in mice
Bas Pilzecker et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Rebuilding Chromosomes After Catastrophe: Emerging Mechanisms of Chromothripsis
Peter Ly et al.
TRENDS IN CELL BIOLOGY (2017)
p21: A Two-Faced Genome Guardian
Alexandros G. Georgakilas et al.
TRENDS IN MOLECULAR MEDICINE (2017)
RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the mammalian brain
Pamela Valnegri et al.
NATURE COMMUNICATIONS (2017)
BRCA2 suppresses replication stress-induced mitotic and G1 abnormalities through homologous recombination
Weiran Feng et al.
NATURE COMMUNICATIONS (2017)
MRE11 and EXO1 nucleases degrade reversed forks and elicit MUS81-dependent fork rescue in BRCA2-deficient cells
Delphine Lemacon et al.
NATURE COMMUNICATIONS (2017)
Replication fork reversal triggers fork degradation in BRCA2-defective cells
Sofija Mijic et al.
NATURE COMMUNICATIONS (2017)
The helicase domain of Polθ counteracts RPA to promote alt-NHEJ
Pedro A. Mateos-Gomez et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2017)
Tetraploid embryonic stem cells can contribute to the development of chimeric fetuses and chimeric extraembryonic tissues
Bingqiang Wen et al.
SCIENTIFIC REPORTS (2017)
Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation
Hisham Mohammed et al.
CELL REPORTS (2017)
Rapid DNA replication origin licensing protects stem cell pluripotency
Jacob Peter Matson et al.
ELIFE (2017)
Mouse blastomeres acquire ability to divide asymmetrically before compaction
Monika Humiecka et al.
PLOS ONE (2017)
Distinct Cell-Cycle Control in Two Different States of Mouse Pluripotency
Menno ter Huurne et al.
CELL STEM CELL (2017)
BLM and SLX4 play opposing roles in recombination-dependent replication at human telomeres
Alexander P. Sobinoff et al.
EMBO JOURNAL (2017)
Zygotic Genome Activation in Vertebrates
David Jukam et al.
DEVELOPMENTAL CELL (2017)
Eukaryotic DNA Replication Fork
Peter M. J. Burgers et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 86 (2017)
Genetic depletion of Polo-like kinase 1 leads to embryonic lethality due to mitotic aberrancies
Paulina Wachowicz et al.
BIOESSAYS (2016)
Genomic Instability in Human Pluripotent Stem Cells Arises from Replicative Stress and Chromosome Condensation Defects
Noa Lamm et al.
CELL STEM CELL (2016)
Mechanism and regulation of DNA end resection in eukaryotes
Lorraine S. Symington
CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY (2016)
Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program
Rossana Foti et al.
MOLECULAR CELL (2016)
LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56
Abhinav K. Jain et al.
MOLECULAR CELL (2016)
Mammalian RAD52 Functions in Break-Induced Replication Repair of Collapsed DNA Replication Forks
Sotirios K. Sotiriou et al.
MOLECULAR CELL (2016)
High-throughput discovery of novel developmental phenotypes
Mary E. Dickinson et al.
NATURE (2016)
Replication fork stability confers chemoresistance in BRCA-deficient cells
Arnab Ray Chaudhuri et al.
NATURE (2016)
ETAA1 acts at stalled replication forks to maintain genome integrity
Thomas E. Bass et al.
NATURE CELL BIOLOGY (2016)
Activation of the ATR kinase by the RPA-binding protein ETAA1
Peter Haahr et al.
NATURE CELL BIOLOGY (2016)
USP7 is a SUMO deubiquitinase essential for DNA replication
Emilio Lecona et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
A short G1 phase imposes constitutive replication stress and fork remodelling in mouse embryonic stem cells
Akshay K. Ahuja et al.
NATURE COMMUNICATIONS (2016)
Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
Xia Ding et al.
NATURE COMMUNICATIONS (2016)
Mouse model of chromosome mosaicism reveals lineage-specific depletion of aneuploid cells and normal developmental potential
Helen Bolton et al.
NATURE COMMUNICATIONS (2016)
USP7 is a SUMO deubiquitinase essential for DNA replication
Emilio Lecona et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016)
5-Hydroxymethylcytosine Marks Sites of DNA Damage and Promotes Genome Stability
Georgia Rose Kafer et al.
CELL REPORTS (2016)
Nucleotide metabolism, oncogene-induced senescence and cancer
Katherine M. Aird et al.
CANCER LETTERS (2015)
Chromothripsis and Kataegis Induced by Telomere Crisis
John Maciejowski et al.
CELL (2015)
Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability
Bo Zhao et al.
CELL STEM CELL (2015)
Differential DNA damage signalling and apoptotic threshold correlate with mouse epiblast-specific hypersensitivity to radiation
Audrey Laurent et al.
DEVELOPMENT (2015)
Polynucleotide kinase-phosphatase enables neurogenesis via multiple DNA repair pathways to maintain genome stability
Mikio Shimada et al.
EMBO JOURNAL (2015)
NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity
Ariana Jacome et al.
EMBO JOURNAL (2015)
DNA2 drives processing and restart of reversed replication forks in human cells
Saravanabhavan Thangavel et al.
JOURNAL OF CELL BIOLOGY (2015)
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Ralph Zellweger et al.
JOURNAL OF CELL BIOLOGY (2015)
Distinct but Concerted Roles of ATR, DNA-PK, and Chk1 in Countering Replication Stress during S Phase
Remi Buisson et al.
MOLECULAR CELL (2015)
Replication stress activates DNA repair synthesis in mitosis
Sheroy Minocherhomji et al.
NATURE (2015)
Mammalian polymerase θ promotes alternative NHEJ and suppresses recombination
Pedro A. Mateos-Gomez et al.
NATURE (2015)
Replication fork reversal in eukaryotes: from dead end to dynamic response
Kai J. Neelsen et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
Tatiana Kent et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
Mammalian RAD51 paralogs protect nascent DNA at stalled forks and mediate replication restart
Kumar Somyajit et al.
NUCLEIC ACIDS RESEARCH (2015)
Autophagy-independent functions of UVRAG are essential for peripheral naive T-cell homeostasis
Samia Afzal et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair
Takashi Ochi et al.
SCIENCE (2015)
Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?
Agnel Sfeir et al.
TRENDS IN BIOCHEMICAL SCIENCES (2015)
Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality
Silvia Alvarez et al.
NATURE COMMUNICATIONS (2015)
Mechanism of microhomology-mediated end-joining promoted by human DNA polymerase θ
Tatiana Kent et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2015)
p53 Suppresses Tetraploid Development in Mice
Takuro Horii et al.
SCIENTIFIC REPORTS (2015)
Embryonic Stem Cells License a High Level of Dormant Origins to Protect the Genome against Replication Stress
Xin Quan Ge et al.
STEM CELL REPORTS (2015)
Reduction of hRNase H2 activity in Aicardi - Goutieres syndrome cells leads to replication stress and genome instability
Sara Pizzi et al.
HUMAN MOLECULAR GENETICS (2015)
Temporal separation of replication and transcription during S-phase progression
Matthieu Meryet-Figuiere et al.
CELL CYCLE (2014)
Base excision repair: A critical player in many games
Susan S. Wallace
DNA REPAIR (2014)
Neural Crest Cell-Specific Inactivation of Nipbl or Mau2 During Mouse Development Results in a Late Onset of Craniofacial Defects
Terence Gordon Smith et al.
GENESIS (2014)
Roles of Chk1 in cell biology and cancer therapy
Youwei Zhang et al.
INTERNATIONAL JOURNAL OF CANCER (2014)
PRP19 Transforms into a Sensor of RPA-ssDNA after DNA Damage and Drives ATR Activation via a Ubiquitin-Mediated Circuitry
Alexandre Marechal et al.
MOLECULAR CELL (2014)
Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining
Hind Ghezraoui et al.
MOLECULAR CELL (2014)
Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells
Johanna Flach et al.
NATURE (2014)
Causes and consequences of replication stress
Michelle K. Zeman et al.
NATURE CELL BIOLOGY (2014)
Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells
Kadir C. Akdemir et al.
NUCLEIC ACIDS RESEARCH (2014)
ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells
Stephen J. Roper et al.
NUCLEIC ACIDS RESEARCH (2014)
GLTSCR2/PICT1 links mitochondrial stress and Myc signaling
John C. Yoon et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells
Lorenzo Costantino et al.
SCIENCE (2014)
Mitosis Inhibits DNA Double-Strand Break Repair to Guard Against Telomere Fusions
Alexandre Orthwein et al.
SCIENCE (2014)
Totipotency: What It Is and What It Isn't
Maureen L. Condic
STEM CELLS AND DEVELOPMENT (2014)
BRCA2 Coordinates the Activities of Cell-Cycle Kinases to Promote Genome Stability
Keiko Yata et al.
CELL REPORTS (2014)
ATR Prohibits Replication Catastrophe by Preventing Global Exhaustion of RPA
Luis Ignacio Toledo et al.
CELL (2013)
Plk1: unexpected roles in DNA replication
Ranadip Mandal et al.
CELL RESEARCH (2013)
The mINO80 chromatin remodeling complex is required for efficient telomere replication and maintenance of genome stability
Jin-Na Min et al.
CELL RESEARCH (2013)
How unfinished business from S-phase affects mitosis and beyond
Hocine W. Mankouri et al.
EMBO JOURNAL (2013)
Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity
Weiqiang Lin et al.
EMBO JOURNAL (2013)
ATR phosphorylates SMARCAL1 to prevent replication fork collapse
Frank B. Couch et al.
GENES & DEVELOPMENT (2013)
Inactivation of Uaf1 Causes Defective Homologous Recombination and Early Embryonic Lethality in Mice
Eunmi Park et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
RIF1 Is Essential for 53BP1-Dependent Nonhomologous End Joining and Suppression of DNA Double-Strand Break Resection
J. Ross Chapman et al.
MOLECULAR CELL (2013)
Regulation of DNA Damage Responses by Ubiquitin and SUMO
Stephen P. Jackson et al.
MOLECULAR CELL (2013)
Replication stress links structural and numerical cancer chromosomal instability
Rebecca A. Burrell et al.
NATURE (2013)
Molecular mechanisms underlying RB protein function
Frederick A. Dick et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Regulation of PCNA-protein interactions for genome stability
Niels Mailand et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells
Audesh Bhat et al.
NUCLEIC ACIDS RESEARCH (2013)
Requirement of SLD5 for Early Embryogenesis
Tomomi Mohri et al.
PLOS ONE (2013)
Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer
Christian Bowman-Colin et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
53BP1 Regulates DSB Repair Using Rif1 to Control 5′ End Resection
Michal Zimmermann et al.
SCIENCE (2013)
Nucleotide Excision Repair in Eukaryotes
Orlando D. Schaerer
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
DNA Damage Sensing by the ATM and ATR Kinases
Alexandre Marechal et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2013)
Nucleolar protein GLTSCR2 stabilizes p53 in response to ribosomal stresses
S. Lee et al.
CELL DEATH AND DIFFERENTIATION (2012)
Activation of the replicative DNA helicase: breaking up is hard to do
Dominik Boos et al.
CURRENT OPINION IN CELL BIOLOGY (2012)
Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion
Miguel Ganuza et al.
EMBO JOURNAL (2012)
Rif1 regulates the replication timing domains on the human genome
Satoshi Yamazaki et al.
EMBO JOURNAL (2012)
Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression
Alireza Baradaran-Heravi et al.
HUMAN MOLECULAR GENETICS (2012)
Mammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrity
Bjoern Hiller et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Distinct Regulatory Mechanisms and Functions for p53-Activated and p53-Repressed DNA Damage Response Genes in Embryonic Stem Cells
Mangmang Li et al.
MOLECULAR CELL (2012)
The zinc-finger domains of PARP1 cooperate to recognize DNA strand breaks
Ammar A. E. Ali et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2012)
The BLM helicase contributes to telomere maintenance through processing of late-replicating intermediate structures
Colleen Barefield et al.
NUCLEIC ACIDS RESEARCH (2012)
DNA Repair in Human Pluripotent Stem Cells Is Distinct from That in Non-Pluripotent Human Cells
Li Z. Luo et al.
PLOS ONE (2012)
Disruption of Murine mp29/Syf2/Ntc31 Gene Results in Embryonic Lethality with Aberrant Checkpoint Response
Chia-Hsin Chen et al.
PLOS ONE (2012)
Cyclin-dependent kinase 1 (Cdk1) is essential for cell division and suppression of DNA re-replication but not for liver regeneration
M. Kasim Diril et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
The p53 network: cellular and systemic DNA damage responses in aging and cancer
H. Christian Reinhardt et al.
TRENDS IN GENETICS (2012)
The RB family is required for the self-renewal and survival of human embryonic stem cells
Jamie F. Conklin et al.
NATURE COMMUNICATIONS (2012)
Proliferating cell nuclear antigen (PCNA): a key factor in DNA replication and cell cycle regulation
Wojciech Strzalka et al.
ANNALS OF BOTANY (2011)
The Werner and Bloom Syndrome Proteins Help Resolve Replication Blockage by Converting (Regressed) Holliday Junctions to Functional Replication Forks
Amrita Machwe et al.
BIOCHEMISTRY (2011)
Double-Strand Break Repair-Independent Role for BRCA2 in Blocking Stalled Replication Fork Degradation by MRE11
Katharina Schlacher et al.
CELL (2011)
TopBP1 Deficiency Causes an Early Embryonic Lethality and Induces Cellular Senescence in Primary Cells
Yoon Jeon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
53BP1 nuclear bodies form around DNA lesions generated by mitotic transmission of chromosomes under replication stress
Claudia Lukas et al.
NATURE CELL BIOLOGY (2011)
Regulation of the MDM2-P53 pathway and tumor growth by PICT1 via nucleolar RPL11
Masato Sasaki et al.
NATURE MEDICINE (2011)
The MRE11 complex: starting from the ends
Travis H. Stracker et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
THOC5/FMIP, an mRNA export TREX complex protein, is essential for hematopoietic primitive cell survival in vivo
Annalisa Mancini et al.
BMC BIOLOGY (2010)
Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis
Olivier Gavet et al.
DEVELOPMENTAL CELL (2010)
Tipin-Replication Protein A Interaction Mediates Chk1 Phosphorylation by ATR in Response to Genotoxic Stress
Michael G. Kemp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Lysine-Specific Demethylase 1 Regulates the Embryonic Transcriptome and CoREST Stability
Charles T. Foster et al.
MOLECULAR AND CELLULAR BIOLOGY (2010)
An overlapping kinase and phosphatase docking site regulates activity of the retinoblastoma protein
Alexander Hirschi et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2010)
Inactivation of HAUSP in vivo modulates p53 function
N. Kon et al.
ONCOGENE (2010)
Mouse Gestation Length Is Genetically Determined
Stephen A. Murray et al.
PLOS ONE (2010)
Origin and formation of the first two distinct cell types of the inner cell mass in the mouse embryo
Samantha A. Morris et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling
Jun-Hyuk Choi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Mouse Embryonic Stem Cells, but Not Somatic Cells, Predominantly Use Homologous Recombination to Repair Double-Strand DNA Breaks
Elisia D. Tichy et al.
STEM CELLS AND DEVELOPMENT (2010)
Loss of Rad51c Leads to Embryonic Lethality and Modulation of Trp53-Dependent Tumorigenesis in Mice
Sergey G. Kuznetsov et al.
CANCER RESEARCH (2009)
A tale of two tails: Activation of DNA damage checkpoint kinase Mec1/ATR by the 9-1-1 clamp and by Dpb11/TopBP1
Vasundhara M. Navadgi-Patil et al.
DNA REPAIR (2009)
Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage
Celine Ziegler-Birling et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY (2009)
Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
Herve Acloque et al.
JOURNAL OF CLINICAL INVESTIGATION (2009)
An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair
Jaan-Olle Andressoo et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
Matilde Murga et al.
NATURE GENETICS (2009)
DNA Polymerase δ Is Required for Early Mammalian Embryogenesis
Arikuni Uchimura et al.
PLOS ONE (2009)
The histone gene activator HINFP is a nonredundant cyclin E/CDK2 effector during early embryonic cell cycles
Ronglin Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
ATR and Chk1 Suppress a Caspase-3-Dependent Apoptotic Response Following DNA Replication Stress
Katie Myers et al.
PLOS GENETICS (2009)
Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation
Jeffrey Buis et al.
CELL (2008)
Polo-Like Kinase 1 Is Essential for Early Embryonic Development and Tumor Suppression
Lin-Yu Lu et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Lymphocyte-specific compensation for XLF/Cernunnos end-joining functions in V(D)J recombination
Gang Li et al.
MOLECULAR CELL (2008)
The basal-like mammary carcinomas induced by Brca1 or Bard1 inactivation implicate the BRCA1/BARD1 heterodimer in tumor suppression
Reena Shakya et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Ubiquitylated PCNA plays a role in somatic hypermutation and class-switch recombination and is required for meiotic progression
Sergio Roa et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Human embryonic stem cells have enhanced repair of multiple forms of DNA damage
Scott Maynard et al.
STEM CELLS (2008)
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice
Yanling Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
Eros Lazzerini Denchi et al.
NATURE (2007)
Hemizygous disruption of Cdc25A inhibits cellular transformation and mammary tumorigenesis in mice
Dipankar Ray et al.
CANCER RESEARCH (2007)
Derivation of pluripotent epiblast stem cells from mammalian embryos
I. Gabrielle M. Brons et al.
NATURE (2007)
New cell lines from mouse epiblast share defining features with human embryonic stem cells
Paul J. Tesar et al.
NATURE (2007)
Role for BLM in replication-fork restart and suppression of origin firing after replicative stress
Sally L. Davies et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2007)
The Rad9-Hus1-Rad1 (9-1-1) clamp activates checkpoint signaling via TopBP1
Sinny Delacroix et al.
GENES & DEVELOPMENT (2007)
Ubiquitin-conjugating enzyme Ubc13 is a critical component of TNF receptor-associated factor (TRAF)-mediated inflammatory responses
Toru Fukushima et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Early embryonic lethality of mice lacking the essential protein SNEV
Klaus Fortschegger et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Targeted inactivation of Fh1 causes proliferative renal cyst development and activation of the hypoxia pathway
Patrick J. Pollard et al.
CANCER CELL (2007)
Cross-talk between Chk1 and Chk2 in double-mutant thymocytes
Kathrin Zaugg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
L2dtl is essential for cell survival and nuclear division in early mouse embryonic development
Chao-Lien Liu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling
Jr-Wen Shui et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Deletion of DDB1 in mouse brain and lens leads to p53-dependent elimination of proliferating cells
Yong Cang et al.
CELL (2006)
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
Giulia B. Celli et al.
NATURE CELL BIOLOGY (2006)
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
Dirk Hockemeyer et al.
CELL (2006)
Thoc1/Hpr1/p84 is essential for early embryonic development in the mouse
Xiaoling Wang et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Early embryonic lethality due to targeted inactivation of DNA ligase III
Nahum Puebla-Osorio et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Two-step activation of ATM by DNA and the Mre11-Rad50-Nbs1 complex
A Dupré et al.
NATURE STRUCTURAL & MOLECULAR BIOLOGY (2006)
Essential dosage-dependent functions of the transcription factor Yin Yang 1 in late embryonic development and cell cycle progression
E Affar et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
TopBP1 activates the ATR-ATRIP complex
A Kumagai et al.
CELL (2006)
An Shp2/SFK/Ras/Erk signaling pathway controls trophoblast stem cell survival
WT Yang et al.
DEVELOPMENTAL CELL (2006)
MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals
ZK Lou et al.
MOLECULAR CELL (2006)
DNA polymerase θ contributes to the generation of C/G mutations during somatic hypermutation of Ig genes
K Masuda et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Cdk1-dependent regulation of the mitotic inhibitor Wee1
SL Harvey et al.
CELL (2005)
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
D Hockemeyer et al.
EMBO JOURNAL (2005)
Mutation in Rpa1 results in defective DNA double-strand break repair, chromosomal instability and cancer in mice
YX Wang et al.
NATURE GENETICS (2005)
Impaired mitotic progression and preimplantation lethality in mice lacking OMCG1, a new evolutionarily conserved nuclear protein
J Artus et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Inactivation of CtIP leads to early embryonic lethality mediated by G1 restraint and to tumorigenesis haploid insufficiency
PL Chen et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
TS Byun et al.
GENES & DEVELOPMENT (2005)
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
JH Lee et al.
SCIENCE (2005)
Disruption of mouse XAB2 gene involved in pre-mRNA splicing, transcription and transcription-coupled DNA repair results in preimplantation lethality
R Yonemasu et al.
DNA REPAIR (2005)
P53 induces differentiation of mouse embryonic stem cells by suppressing Nanog expression
TX Lin et al.
NATURE CELL BIOLOGY (2005)
Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus
A Li et al.
EMBO JOURNAL (2005)
M-phase kinases induce phospho-dependent ubiquitination of somatic Wee1 by SCFβ-TrCP
N Watanabe et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Abasic sites in DNA:: repair and biological consequences in Saccharomyces cerevisiae
S Boiteux et al.
DNA REPAIR (2004)
Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
M Audebert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The mouse genomic instability mutation chaos1 is an allele of Polq that exhibits genetic interaction with Atm
N Shima et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Dynamics of global gene expression changes during mouse preimplantation development
T Hamatani et al.
DEVELOPMENTAL CELL (2004)
Multiple functions of Jab1 are required for early embryonic development and growth potential in mice
K Tomoda et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Requirement of the MRN complex for ATM activation by DNA damage
T Uziel et al.
EMBO JOURNAL (2003)
Growth retardation and skin abnormalities of the Recq/4-deficient mouse
Y Hoki et al.
HUMAN MOLECULAR GENETICS (2003)
Proliferation failure and gamma radiation sensitivity of Fen1 null mutant mice at the blastocyst stage
E Larsen et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Loss of Bard1, the heterodimeric partner of the Brca1 tumor suppressor, results in early embryonic lethality and chromosomal instability
EE McCarthy et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents
Z Xiao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Parp1-deficiency induces differentiation of ES cells into trophoblast derivatives
M Hemberger et al.
DEVELOPMENTAL BIOLOGY (2003)
p53 binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice
IM Ward et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
BRCT domain-containing protein PTIP is essential for progression through mitosis
EA Cho et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
MDC1 is a mediator of the mammalian DNA damage checkpoint
GS Stewart et al.
NATURE (2003)
Loading of the human 9-1-1 checkpoint complex onto DNA by the checkpoint clamp loader hRad17-replication factor C complex in vitro
VP Bermudez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Checkpoint failure and chromosomal instability without lymphomagenesis in Mre11(ATLD1/ATLD1) mice
JWF Theunissen et al.
MOLECULAR CELL (2003)
CUL-4A is critical for early embryonic development
BH Li et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Genomic instability in mice lacking histone H2AX
A Celeste et al.
SCIENCE (2002)
Inactivation of Cdc7 kinase in mouse ES cells results in S-phase arrest and p53-dependent cell death
JM Kim et al.
EMBO JOURNAL (2002)
The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition
EA Carver et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
The human licensing factor for DNA replication Cdt1 accumulates in G1 and is destabilized after initiation of S-phase
H Nishitani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
ATR and ATRIP: Partners in checkpoint signaling
D Cortez et al.
SCIENCE (2001)
Requirement of CDC45 for postimplantation mouse development
K Yoshida et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
TFIIH: from transcription to clinic
JM Egly
FEBS LETTERS (2001)
Inability to enter S phase and defective RNA polymerase IICTD phosphorylation in mice lacking Mat1
DJ Rossi et al.
EMBO JOURNAL (2001)
Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice
J Zhu et al.
CURRENT BIOLOGY (2001)
Mitotic kinases as regulators of cell division and its checkpoints
EA Nigg
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Disruption of mouse polymerase ζ (Rev3) leads to embryonic lethality and impairs blastocyst development in vitro
M Bemark et al.
CURRENT BIOLOGY (2000)
A time-less function for mouse Timeless
AL Gotter et al.
NATURE NEUROSCIENCE (2000)
Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice
A de Klein et al.
CURRENT BIOLOGY (2000)
分享论文
