期刊
GUT MICROBES
卷 11, 期 5, 页码 1203-1219出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2020.1758008
关键词
Tryptophan metabolites; microbiome-gut-brain axis; vagal; aryl hydrocarbon receptor (AhR); central nervous system (CNS)
资金
- National Key R&D Program of China [2018YFD0500601, 2017YFD0500501]
- National Natural Science Foundation of China [31930106, 31829004, 31722054]
- National Ten-thousand Talents Program of China [23070201]
- 111 project [B16044]
Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the interface of microbiome-gut-brain axis. However, the pathway through which Trp metabolites affect central nervous system (CNS) function have not been fully elucidated. AhR participates in a broad variety of physiological and pathological processes that also highly relevant to intestinal homeostasis and CNS diseases. Via the AhR-dependent mechanism, Trp metabolites connect bidirectional signaling between the gut microbiome and the brain, mediated via immune, metabolic, and neural (vagal) signaling mechanisms, with downstream effects on behavior and CNS function. These findings shed light on the complex Trp regulation of microbiome-gut-brain axis and add another facet to our understanding that dietary Trp is expected to be a promising noninvasive approach for alleviating systemic diseases.
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