4.7 Review

Host-microbiome interactions: the aryl hydrocarbon receptor as a critical node in tryptophan metabolites to brain signaling

期刊

GUT MICROBES
卷 11, 期 5, 页码 1203-1219

出版社

TAYLOR & FRANCIS INC
DOI: 10.1080/19490976.2020.1758008

关键词

Tryptophan metabolites; microbiome-gut-brain axis; vagal; aryl hydrocarbon receptor (AhR); central nervous system (CNS)

资金

  1. National Key R&D Program of China [2018YFD0500601, 2017YFD0500501]
  2. National Natural Science Foundation of China [31930106, 31829004, 31722054]
  3. National Ten-thousand Talents Program of China [23070201]
  4. 111 project [B16044]

向作者/读者索取更多资源

Tryptophan (Trp) is not only a nutrient enhancer but also has systemic effects. Trp metabolites signaling through the well-known aryl hydrocarbon receptor (AhR) constitute the interface of microbiome-gut-brain axis. However, the pathway through which Trp metabolites affect central nervous system (CNS) function have not been fully elucidated. AhR participates in a broad variety of physiological and pathological processes that also highly relevant to intestinal homeostasis and CNS diseases. Via the AhR-dependent mechanism, Trp metabolites connect bidirectional signaling between the gut microbiome and the brain, mediated via immune, metabolic, and neural (vagal) signaling mechanisms, with downstream effects on behavior and CNS function. These findings shed light on the complex Trp regulation of microbiome-gut-brain axis and add another facet to our understanding that dietary Trp is expected to be a promising noninvasive approach for alleviating systemic diseases.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据