期刊
NATURE HUMAN BEHAVIOUR
卷 4, 期 5, 页码 544-+出版社
NATURE PORTFOLIO
DOI: 10.1038/s41562-020-0846-5
关键词
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资金
- European Union [LSHM-CT-2007-037286]
- Horizon 2020 [695313]
- National Natural Science Foundation of China [81801773, 81873909]
- Shanghai Pujiang Project [18PJ1400900]
- ERANID [PR-ST-0416-10004]
- BRIDGET (JPND brain imaging, cognition, dementia and next generation GEnomics) [MR/N027558/1]
- Human Brain Project (SGA 2) [785907]
- FP7 project MATRICS [603016]
- Medical Research Council Grant 'c-VEDA' (consortium on vulnerability to externalizing disorders and addictions) [MR/N000390/1]
- National Institute of Health (NIH) [R01DA049238]
- National Institute for Health Research Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- Bundesministerium fur Bildung und Forschung [01GS08152, 01EV0711]
- Bundesministerium fur Bildung und Forschung (Forschungsnetz AERIAL) [01EE1406A, 01EE1406B]
- Deutsche Forschungsgemeinschaft (DFG) [SM 80/7-2, SFB 940, TRR 265, NE 1383/14-1]
- Medical Research Foundation
- Medical Research Council [MR/R00465X/1, MR/S020306/1]
- National Institutes of Health (NIH) [5U54EB020403-05, 1R56AG058854-01]
- ANR [ANR-12-SAMA-0004, AAPG2019 -GeBra]
- Eranet Neuron [AF12NEUR0008-01 - WM2NA, ANR-18-NEUR00002-01 - ADORe]
- Fondation de France [00081242]
- Fondation pour la Recherche Medicale [DPA20140629802]
- Mission Interministerielle de Lutte Contre les Drogues et les Conduites Addictives (MILDECA)
- Assistance-Publique - Hopitaux de Paris
- INSERM (interface grant), Paris Sud University IDEX 2012
- Fondation de l'Avenir [AP-RM-17013]
- Federation pour la Recherche sur le Cerveau
- National Institutes of Health
- Science Foundation Ireland [16/ERCD/3797]
- U.S.A. (Axon, Testosterone and Mental Health during Adolescence) [RO1 MH085772-01A1]
- NIH Consortium grant [U54 EB020403]
- cross-NIH alliance
- 111 Project [B18015]
- National Key Research and Development Program of China [2018YFC0910503, 2018YFC1312900]
- NSFC [81930095, 91630314]
- Key Project of Shanghai Science and Technology Innovation Plan [16JC1420402]
- Shanghai Municipal Science and Technology Major Project [2018SHZDZX01]
- Zhangjiang Lab
- Human Brain Project (SGA 3) [945539]
- Medical Research Council [MR/R00465X/1, MR/S020306/1] Funding Source: researchfish
- Medical Research Foundation [MRF-058-0004-RG-DESRI, MRF-058-0009-RG-DESR-C0759] Funding Source: researchfish
- MRC [MR/N000390/1, MR/N027558/1, MR/S020306/1, MR/R00465X/1] Funding Source: UKRI
On the basis of the IMAGEN database of 2,000 Caucasian adolescents, Jia et al identify neural patterns of activity during reward anticipation and motor inhibition associated with different externalising symptoms for ADHD and conduct problems. Reinforcement-related cognitive processes, such as reward processing, inhibitory control and social-emotional regulation are critical components of externalising and internalising behaviours. It is unclear to what extent the deficit in each of these processes contributes to individual behavioural symptoms, how their neural substrates give rise to distinct behavioural outcomes and whether neural activation profiles across different reinforcement-related processes might differentiate individual behaviours. We created a statistical framework that enabled us to directly compare functional brain activation during reward anticipation, motor inhibition and viewing emotional faces in the European IMAGEN cohort of 2,000 14-year-old adolescents. We observe significant correlations and modulation of reward anticipation and motor inhibition networks in hyperactivity, impulsivity, inattentive behaviour and conduct symptoms, and we describe neural signatures across cognitive tasks that differentiate these behaviours. We thus characterise shared and distinct functional brain activation patterns underling different externalising symptoms and identify neural stratification markers, while accounting for clinically observed comorbidity.
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