期刊
JOURNAL OF THE AMERICAN ASSOCIATION OF NURSE PRACTITIONERS
卷 33, 期 6, 页码 419-428出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JXX.0000000000000397
关键词
Abortive treatment; acute treatment; calcitonin gene-related peptide; migraine disorders; nurse practitioners
资金
- Allergan plc, Dublin, Ireland
The study found that 40% of migraine patients report at least one unmet treatment need, mainly due to the inability to use existing medications. Oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated potential efficacy in treating migraines.
Background: Migraine is a prevalent and chronic disease associated with high rates of disability and significant financial and socioeconomic burden. Current acute treatments for migraine attacks include both migraine-specific (e.g., triptans, ergotamines) and nonspecific (e.g., nonsteroidal anti-inflammatory drugs) medications; however, significant unmet treatment needs remain. Objectives: The authors sought to characterize the nature and drivers of unmet treatment needs in the acute treatment of migraine attacks and describe emerging migraine-specific treatments, that is, calcitonin gene-related peptide (CGRP) receptor antagonists. Data sources: PubMed searches were conducted using search terms for studies of unmet migraine treatment needs and CGRP receptor antagonists. Additionally, studies presented at recent headache-focused congresses were included. Conclusions: Forty percent of people with migraine report at least 1 unmet treatment need. Many people are unable to use migraine-specific or nonspecific agents because of contraindications, precautions, and tolerability issues. Disease burden (disability, headache severity/frequency) remains high even in those receiving migraine-specific medications. The oral CGRP receptor antagonists, ubrogepant and rimegepant, demonstrated efficacy in reducing migraine pain, migraine-associated symptoms, and disability, with a low adverse event profile, similar to placebo. Implications for practice: The availability and use of CGRP receptor antagonists may help reduce the extent of unmet needs in the treatment of migraine attacks, resulting in more patients receiving treatment and better outcomes for people with migraine. Nurse practitioners are well positioned to increase rates of migraine diagnosis/treatment (another key unmet need), using consensus guidelines to guide their approach.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据