期刊
FRONTIERS IN MATERIALS
卷 7, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fmats.2020.00061
关键词
alginate microfibers; graphene; conductivity; cell encapsulation; 3D cell coculture; microfluidics; neural cells
资金
- Office of Naval Research Grant (ONR) [N000141612246]
- ONR [N000141712620]
- Iowa State University Multiscale Sensing Actuation and Imaging (MoSAIc) Research Experience for Undergraduates program
- Iowa State University Honor's Program
- U.S. Department of Defense (DOD) [N000141612246] Funding Source: U.S. Department of Defense (DOD)
Microfluidically manufacturing graphene-alginate microfibers create possibilities for encapsulating rat neural cells within conductive 3D tissue scaffolding to enable the creation of real-time 3D sensing arrays with high physiological relavancy. Cells are encapsulated using the biopolymer alginate, which is combined with graphene to create a cell-containing hydrogel with increased electrical conductivity. Resulting novel alginate-graphene microfibers showed a 2.5-fold increase over pure alginate microfibers, but did not show significant differences in size and porosity. Cells encapsulated within the microfibers survive for up to 8 days, and maintain similar to 20% live cells over that duration. The biocompatible aqueous graphene suspension used in this investigation was obtained via liquid phase exfoliation of pristine graphite, to create a graphene-alginate pre-hydrogel solution.
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