期刊
BLOOD
卷 126, 期 15, 页码 1831-1834出版社
AMER SOC HEMATOLOGY
DOI: 10.1182/blood-2015-04-637702
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- Department of Health (England)
- National Institute for Health Research
- Wellcome Trust
- National Institute for Health Research [RP-PG-0310-1004] Funding Source: researchfish
During maturation to an erythrocyte, a reticulocyte must eliminate any residual organelles andreduce itssurface area and volume. Here we show this involves a novel process where by large, intact, inside-out phosphatidylserine (PS)-exposed autophagic vesicles are extruded. Cell surface PS is a well-characterized apoptotic signal initiating phagocytosis. In peripheral blood from patients after splenectomy or in patients with sickle cell disease (SCD), the number of circulating red cells exposing PS on their surface is elevated. We show that in these patients PS is present on the cell surface of red cells in large (similar to 1.4 mu m) discrete areas corresponding to autophagic vesicles. The autophagic vesicles found on reticulocytes are identical to those observed on red cells from splenectomized individuals and patients with SCD. Our data suggest the increased thrombotic risk associated with splenectomy, and patients with hemoglobinopathies is a possible consequence of increased levels of circulating mature reticulocytes expressing inside-out PS-exposed autophagic vesicles because of asplenia.
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