期刊
BIOMEDICAL JOURNAL
卷 44, 期 2, 页码 157-164出版社
ELSEVIER
DOI: 10.1016/j.bj.2020.05.006
关键词
Extracellular vesicles; Immune response; Bacterial infection
资金
- NIH [R21AI146521, P20GM121293]
- USDAARS Project [6026-51000-010-06S]
Extracellular vesicle biology focuses on understanding cellular communication mechanisms, with studies indicating that EVs released during bacterial infection can impact host immune response and bacterial growth. However, the mechanisms behind EV release and their effects on the immune system require further investigation.
Extracellular vesicle (EV) biology involves understanding the cellular and molecular mechanisms of cell communication. Studies conducted so far with various bacterial infection models demonstrate the release of various types of EVs that include exosomes and microvesicles. Depending upon the infection and cell type, EV cargo composition changes and ultimately might impact the host immune response and bacterial growth. The mechanisms behind the EVs release, cargo composition, and impact on the immune system have not been fully investigated. Future research needs to include in vivo models to understand the relevance of EVs in host immune function during bacterial infection, and to determine aspects that are shared or species-specific in the host. This would aid in the development of EVs as therapeutics or as markers of disease.
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