期刊
OPEN FORUM INFECTIOUS DISEASES
卷 7, 期 6, 页码 -出版社
OXFORD UNIV PRESS INC
DOI: 10.1093/ofid/ofaa206
关键词
onchocerciasis; epilepsy; causal relationship; Africa; cohort
资金
- Helen Keller International
- Institut de Recherche pour le Developpement
To confirm our earlier evidence of a temporal and dose-response relationship between onchocerciasis and epilepsy, we conducted another cohort study in a different setting in Cameroon. Individuals whose Onchocerca volvulus microfilarial density (Ov-MFD) was measured in 1992-1994 when they were children were revisited in 2019 to determine if they acquired epilepsy. With reference to individuals with no microfilariae in 1992-1994, the relative risks of acquiring epilepsy were 0.96, 2.76, 3.67, and 11.87 in subjects with initial Ov-MFD of 1-7, 8-70, 71-200, and > 200 microfilariae per skin snip, respectively. This study further demonstrates reproducibility using the Bradford Hill's criteria for causality.
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