期刊
JOURNAL OF ADVANCED RESEARCH
卷 23, 期 -, 页码 13-23出版社
ELSEVIER
DOI: 10.1016/j.jare.2020.01.011
关键词
Photothermal imaging; Photothermal therapy; Photodynamic therapy; Sonodynamic effect; Multimodal synergistic antitumor
资金
- Natural Science Foundation of Anhui Province [1908085QE224]
- Major Science and Technology Projects of Anhui Province [18030701213]
- Anhui Province Foundation of China [GXBJZD21]
- Nature Science Research Programme of the Education Office of Anhui Province of China [KJ2019A05270]
- Talent Project of Fuyang Normal University [2018kyqd0034, 2018kyqd0029]
- College and Enterprise Cooperative Project [XDHX2016009]
- Innovative Training Program for College Students of Anhui Province [S201910371023]
For facilitating theranostic nanoplatform with multimodal therapeutic ability, we develop the core-shell structured CDs@SiO2@TiO2 nanoplatforms (CST NPs). The designed CST NPs possess excellent photothermal effect and fluorescence resonance energy transfer (FRET) induced photodynamic property, which could achieve synergistic photothermal and photodynamic therapy. Meanwhile, the photothermal ability of CST NPs acts as a key role in the application of real-time photothermal imaging, benefitting for the diagnosis of tumor accurately. Moreover, the obtained CST NPs also exhibit outstanding sonodynamic effect with huge potential for sonodynamic therapy. Under the 650 nm laser irradiation, the synthesized CST NPs not only inhibit the growth of cancer cells in vitro, but also display precise photothermal imaging and photo-induced ablation to tumor in vivo. As a result, the prepared CST NPs may potentially serve as multifunctional nanoplatform for theranostic antitumor and pave the avenue for clinic cancer therapy. (C) 2020 The Authors. Published by Elsevier B.V. on behalf of Cairo University.
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