期刊
FRONTIERS IN ONCOLOGY
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fonc.2020.00727
关键词
cancer; growth factors; insulin; binding proteins; mechanism; cross-talk
类别
资金
- 2019 Shiyan Taihe Hospital Foundation Program [2019 JJXM020]
- Stollery Children's Hospital Foundation
- Lois Hole Hospital for Women through the Women and Children's Health Research Institute (WCHRI)
- Hubei Province Natural Science Funding for Hubei University of Technology
- osterreichische Krebshilfe Tyrol (Krebsgesellschaft Tirol, Austrian Tyrolean Cancer Research Institute, 2008)
- Austrian Research Fund (Fonds zur Forderung der wissenschaftlichen Forschung)
- Canadian Foundation for Women's Health
- Cancer Research Society
- Canadian Institutes of Health Research
- Saudi Cultural Bureau, Ottawa, Canada
The insulin/insulin-like growth factors (IGFs) have crucial tasks in the growth, differentiation, and proliferation of healthy and pernicious cells. They are involved in coordinated complexes, including receptors, ligands, binding proteins, and proteases. However, the systems can become dysregulated in tumorigenesis. Insulin-like growth factor-binding protein 7 (IGFBP7) is a protein belonging to the IGFBP superfamily (also termed GFBP-related proteins). Numerous studies have provided evidence that IGFBP3 and IGFBP7 are involved in a variety of cancers, including hepatocellular carcinoma (HCC), breast cancer, gastroesophageal cancer, colon cancer, prostate cancer, among many others. Still, very few suggest an interaction between these two molecules. In studying several cancer types in our laboratories, we found that both proteins share some crucial signaling pathways. The objective of this review is to present a comprehensive overview of the relationship between IGFBP7 and cancer, as well as highlighting IGFBP3 crosstalk with IGFBP7 reported in recent studies.
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