相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Cellular adaptation to hypoxia through hypoxia inducible factors and beyond
Pearl Lee et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)
Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer
Sandhya Chipurupalli et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Reference MicroRNAs for RT-qPCR Assays in Cervical Cancer Patients and Their Application to Studies of HPV16 and Hypoxia Biomarkers
Anja Nilsen et al.
TRANSLATIONAL ONCOLOGY (2019)
Acute Hypoxia Profile is a Stronger Prognostic Factor than Chronic Hypoxia in Advanced Stage Head and Neck Cancer Patients
Martijn van der Heijden et al.
CANCERS (2019)
Inherent DNA-binding specificities of the HIF-1α and HIF-2α transcription factors in chromatin
James A. Smythies et al.
EMBO REPORTS (2019)
Molecular landmarks of tumor hypoxia across cancer types
Vinayak Bhandari et al.
NATURE GENETICS (2019)
CD4+ and CD8a+ PET imaging predicts response to novel PD-1 checkpoint inhibitor: studies of Sym021 in syngeneic mouse cancer models
Lotte K. Kristensen et al.
THERANOSTICS (2019)
Challenges to DNA replication in hypoxic conditions
Natalie Ng et al.
FEBS JOURNAL (2018)
IRE1α RNase-dependent lipid homeostasis promotes survival in Myc-transformed cancers
Hong Xie et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Immunological Approaches Towards Cancer and Inflammation: A Cross Talk
Xinglong Qu et al.
FRONTIERS IN IMMUNOLOGY (2018)
Development and Validation of a 28-gene Hypoxia-related Prognostic Signature for Localized Prostate Cancer
Lingjian Yang et al.
EBIOMEDICINE (2018)
Immuno PET imaging of PD-L1 expression in syngeneic and human xenograft tumor mouse models using a site-specific 89Zr labeled PD-L1 antibody
Camilla Christensen et al.
CANCER RESEARCH (2018)
Roles of the immune system in cancer: from tumor initiation to metastatic progression
Hugo Gonzalez et al.
GENES & DEVELOPMENT (2018)
Zr-89-atezolizumab imaging as a non-invasive approach to assess clinical response to PD-L1 blockade in cancer
Frederike Bensch et al.
NATURE MEDICINE (2018)
Signature of cytokines and angiogenic factors (CAFs) defines a clinically distinct subgroup of gastric cancer
Chan-Young Ock et al.
GASTRIC CANCER (2017)
New horizons in hypoxia signaling pathways
Christopher W. Pugh et al.
EXPERIMENTAL CELL RESEARCH (2017)
Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor immunity: Adenosine, Lactate, Acidosis, vascular endothelial Growth Factor, Potassium ions, and Phosphatidylserine
Peter Vaupel et al.
FRONTIERS IN IMMUNOLOGY (2017)
Combining radiotherapy with immunotherapy: the past, the present and the future
Evert J. Van Limbergen et al.
BRITISH JOURNAL OF RADIOLOGY (2017)
Realizing the Potential of Vascular Targeted Therapy: The Rationale for Combining Vascular Disrupting Agents and Anti-Angiogenic Agents to Treat Cancer
D. W. Siemann et al.
CANCER INVESTIGATION (2017)
Validation of a 15-gene hypoxia classifier in head and neck cancer for prospective use in clinical trials
Kasper Toustrup et al.
ACTA ONCOLOGICA (2016)
Expression of miR-210 in relation to other measures of hypoxia and prediction of benefit from hypoxia modification in patients with bladder cancer
J. J. Irlam-Jones et al.
BRITISH JOURNAL OF CANCER (2016)
Integrative Analysis of DCE-MRI and Gene Expression Profiles in Construction of a Gene Classifier for Assessment of Hypoxia-Related Risk of Chemoradiotherapy Failure in Cervical Cancer
Christina S. Fjeldbo et al.
CLINICAL CANCER RESEARCH (2016)
Low Cancer Stem Cell Marker Expression and Low Hypoxia Identify Good Prognosis Subgroups in HPV(-) HNSCC after Postoperative Radiochemotherapy: A Multicenter Study of the DKTK-ROG
Annett Linge et al.
CLINICAL CANCER RESEARCH (2016)
Immuno-oncology: Allying forces of radio- and immuno-therapy to enhance cancer cell killing
Jacques Bernier
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2016)
Sorafenib Increases Tumor Hypoxia in Cervical Cancer Patients Treated With Radiation Therapy: Results of a Phase 1 Clinical Study
Michael F. Milosevic et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2016)
Hypoxia-inducible factors: a central link between inflammation and cancer
Daniel Triner et al.
JOURNAL OF CLINICAL INVESTIGATION (2016)
The tumour hypoxia induced non-coding transcriptome
Hani Choudhry et al.
MOLECULAR ASPECTS OF MEDICINE (2016)
Comparative analysis of transcriptomics based hypoxia signatures in head- and neck squamous cell carcinoma
Bouchra Tawk et al.
RADIOTHERAPY AND ONCOLOGY (2016)
Prognostic value of blood-biomarkers related to hypoxia, inflammation, immune response and tumour load in non-small cell lung cancer - A survival model with external validation
Sara Carvalho et al.
RADIOTHERAPY AND ONCOLOGY (2016)
An evaluation of multiplex bead-based analysis of cytokines and soluble proteins in archived lithium heparin plasma, EDTA plasma and serum samples
Line Brondum et al.
SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION (2016)
Hypoxic control of metastasis
Erinn B. Rankin et al.
SCIENCE (2016)
Pathophysiological Basis for the Formation of the Tumor Microenvironment
Michael R. Horsman et al.
FRONTIERS IN ONCOLOGY (2016)
Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity
Thomas Kietzmann et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
Signaling pathways and mechanisms of hypoxia-induced autophagy in the animal cells
Yungyun Fang et al.
CELL BIOLOGY INTERNATIONAL (2015)
Gene Expression Signatures as Biomarkers of Tumour Hypoxia
B. H. L. Harris et al.
CLINICAL ONCOLOGY (2015)
Immune Checkpoint Blockade in Cancer Therapy
Michael A. Postow et al.
JOURNAL OF CLINICAL ONCOLOGY (2015)
Modulation of the tumor vasculature and oxygenation to improve therapy
Dietmar W. Siemann et al.
PHARMACOLOGY & THERAPEUTICS (2015)
Simultaneous Hypoxia and Low Extracellular pH Suppress Overall Metabolic Rate and Protein Synthesis In Vitro
Brita Singers Sorensen et al.
PLOS ONE (2015)
Immunological mechanisms of the antitumor effects of supplemental oxygenation
Stephen M. Hatfield et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
The tumour hypoxia marker pimonidazole reflects a transcriptional programme associated with aggressive prostate cancer
H. B. Ragnum et al.
BRITISH JOURNAL OF CANCER (2015)
LET-painting increases tumour control probability in hypoxic tumours
Niels Bassler et al.
ACTA ONCOLOGICA (2014)
HypoxamiRs and Cancer: From Biology to Targeted Therapy
Harriet E. Gee et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Mechanisms of Hypoxia-Mediated Immune Escape in Cancer
Ivraym B. Barsoum et al.
CANCER RESEARCH (2014)
PD-L1 is a novel direct target of HIF-1α., and its blockade under hypoxia enhanced MDSC-mediated T cell activation
Muhammad Zaeem Noman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2014)
XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway
Xi Chen et al.
NATURE (2014)
Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer
Charles G. Drake et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2014)
A 26-Gene Hypoxia Signature Predicts Benefit from Hypoxia-Modifying Therapy in Laryngeal Cancer but Not Bladder Cancer
Amanda Eustace et al.
CLINICAL CANCER RESEARCH (2013)
Prospective technical validation and assessment of intra-tumour heterogeneity of a low density array hypoxia gene profile in head and neck squamous cell carcinoma
Guy N. J. Betts et al.
EUROPEAN JOURNAL OF CANCER (2013)
Improved tumor oxygenation and survival in glioblastoma patients who show increased blood perfusion after cediranib and chemoradiation
Tracy T. Batchelor et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Immunologically augmented cancer treatment using modern radiotherapy
Marco Durante et al.
TRENDS IN MOLECULAR MEDICINE (2013)
Hypoxia-Inducible Factors in Physiology and Medicine
Gregg L. Semenza
CELL (2012)
Accelerated Radiotherapy With Carbogen and Nicotinamide for Laryngeal Cancer: Results of a Phase III Randomized Trial
Geert O. Janssens et al.
JOURNAL OF CLINICAL ONCOLOGY (2012)
Imaging hypoxia to improve radiotherapy outcome
Michael R. Horsman et al.
NATURE REVIEWS CLINICAL ONCOLOGY (2012)
Hypoxia Gene Expression Signatures as Prognostic and Predictive Markers in Head and Neck Radiotherapy
Kasper Toustrup et al.
SEMINARS IN RADIATION ONCOLOGY (2012)
HIF-1 versus HIF-2 - Is one more important than the other?
Agnieszka Loboda et al.
VASCULAR PHARMACOLOGY (2012)
Single-Photon Emission Computed Tomographic Imaging of the Early Time Course of Therapy-Induced Cell Death Using Technetium 99m Tricarbonyl His-Annexin A5 in a Colorectal Cancer Xenograft Model
Christel Vangestel et al.
MOLECULAR IMAGING (2012)
Development of a Hypoxia Gene Expression Classifier with Predictive Impact for Hypoxic Modification of Radiotherapy in Head and Neck Cancer
Kasper Toustrup et al.
CANCER RESEARCH (2011)
ACUTE VERSUS CHRONIC HYPOXIA: WHY A SIMPLIFIED CLASSIFICATION IS SIMPLY NOT ENOUGH
Christine Bayer et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2011)
Metastatic Renal Cell Carcinoma: Relationship Between Initial Metastasis Hypoxia, Change After 1 Month's Sunitinib, and Therapeutic Response: An 18F-Fluoromisonidazole PET/CT Study
Florent Hugonnet et al.
JOURNAL OF NUCLEAR MEDICINE (2011)
Bevacizumab impairs oxidative energy metabolism and shows antitumoral effects in recurrent glioblastomas: a 31P/1H MRSI and quantitative magnetic resonance imaging study
Elke Hattingen et al.
NEURO-ONCOLOGY (2011)
Otto Warburg's contributions to current concepts of cancer metabolism
Willem H. Koppenol et al.
NATURE REVIEWS CANCER (2011)
Identifying pH independent hypoxia induced genes in human squamous cell carcinomas in vitro
Brita Singers Sorensen et al.
ACTA ONCOLOGICA (2010)
Large meta-analysis of multiple cancers reveals a common, compact and highly prognostic hypoxia metagene
F. M. Buffa et al.
BRITISH JOURNAL OF CANCER (2010)
Targeting Hypoxic Cells through the DNA Damage Response
Monica Olcina et al.
CLINICAL CANCER RESEARCH (2010)
Hypoxia-induced autophagy: cell death or cell survival?
Nathalie M. Mazure et al.
CURRENT OPINION IN CELL BIOLOGY (2010)
IMPROVED INTRATUMORAL OXYGENATION THROUGH VASCULAR NORMALIZATION INCREASES GLIOMA SENSITIVITY TO IONIZING RADIATION
Mackenzie C. McGee et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2010)
Bevacizumab-induced tumor vessel remodeling in rhabdomyosarcoma xenografts increases the effectiveness of adjuvant ionizing radiation
Adrianne L. Myers et al.
JOURNAL OF PEDIATRIC SURGERY (2010)
Serum Signature of Hypoxia-Regulated Factors Is Associated with Progression after Induction Therapy in Head and Neck Squamous Cell Cancer
Lauren Averett Byers et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Cell surface nucleolin antagonist causes endothelial cell apoptosis and normalization of tumor vasculature
Valentina Fogal et al.
ANGIOGENESIS (2009)
Preventing oxidative stress: a new role for XBP1
Y. Liu et al.
CELL DEATH AND DIFFERENTIATION (2009)
Cytoplasmic functions of the tumour suppressor p53
Douglas R. Green et al.
NATURE (2009)
Plasma Osteopontin, Hypoxia, and Response to Radiotherapy in Nasopharyngeal Cancer
Edwin P. Hui et al.
CLINICAL CANCER RESEARCH (2008)
hsa-miR-210 is induced by hypoxia and is an independent prognostic factor in breast cancer
Carme Camps et al.
CLINICAL CANCER RESEARCH (2008)
Transcriptional control of human p53-regulated genes
Todd Riley et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
The Genomic Analysis of Lactic Acidosis and Acidosis Response in Human Cancers
Julia Ling-Yu Chen et al.
PLOS GENETICS (2008)
Hypoxia, DNA repair and genetic instability
Robert G. Bristow et al.
NATURE REVIEWS CANCER (2008)
Signal integration in the endoplasmic reticulum unfolded protein response
David Ron et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2007)
Hypoxia induced expression of endogenous markers in vitro is highty influenced by pH
Brita Singers Sorensen et al.
RADIOTHERAPY AND ONCOLOGY (2007)
Impact of supervised gene signatures of early hypoxia on patient survival
Renaud Seigneuric et al.
RADIOTHERAPY AND ONCOLOGY (2007)
Scheduling of radiation with angiogenesis inhibitors anginex and avastin improves therapeutic outcome via vessel normalization
Ruud P. M. Dings et al.
CLINICAL CANCER RESEARCH (2007)
Relation of a hypoxia metagene derived from head and neck cancer to prognosis of multiple cancers
Stuart C. Winter et al.
CANCER RESEARCH (2007)
Pathophysiologic effects of vascular-targeting agents and the implications for combination with conventional therapies
Michael R. Horsman et al.
CANCER RESEARCH (2006)
Potentiation of cyclophosphamide chemotherapy using the anti-angiogenic drug thalidomide: Importance of optimal scheduling to exploit the 'normalization' window of the tumor vasculature
Jerome Segers et al.
CANCER LETTERS (2006)
Plasma osteopontin is an independent prognostic marker for head and neck cancers
David Petrik et al.
JOURNAL OF CLINICAL ONCOLOGY (2006)
Mechanism of reoxygenation after antianglogenic therapy using SU5416 and its importance for guiding combined antitumor therapy
Reginald Ansiaux et al.
CANCER RESEARCH (2006)
Plasma osteopontin levels in patients with head and neck cancer and cervix cancer are critically dependent on the choice of ELISA system
Dirk Vordermark et al.
BMC CANCER (2006)
Cell-specific regulation of hypoxia-inducible factor (HIF)-1α and HIF-2α stabilization and transactivation in a graded oxygen environment
Cameron P. Bracken et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Translating tumor hypoxia: Unfolded protein response (UPR)-dependent and UPR-independent pathways
Constantinos Koumenis et al.
MOLECULAR CANCER RESEARCH (2006)
Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control
M Koritzinsky et al.
EMBO JOURNAL (2006)
Relationship between radiobiological hypoxia in a C3H mouse mammary carcinoma and osteopontin levels in mouse serum
S Lukacova et al.
INTERNATIONAL JOURNAL OF RADIATION BIOLOGY (2005)
The unfolded protein response: A novel component of the hypoxic stress response in tumors
DE Feldman et al.
MOLECULAR CANCER RESEARCH (2005)
Plasma osteopontin, hypoxia, and response to the hypoxia sensitiser nimorazole in radiotherapy of head and neck cancer: results from the DAHANCA 5 randomised double-blind placebo-controlled trial
J Overgaard et al.
LANCET ONCOLOGY (2005)
Comparison of different methods of CAIX quantification in relation to hypoxia in three human head and neck tumor lines
EGC Troost et al.
RADIOTHERAPY AND ONCOLOGY (2005)
Influence of oxygen concentration and pH on expression of hypoxia induced genes
BS Sorensen et al.
RADIOTHERAPY AND ONCOLOGY (2005)
Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors
BM Fenton et al.
CANCER RESEARCH (2004)
Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation: Role of oxygenation, angiopoietin-1, and matrix metal loproteinases
F Winkler et al.
CANCER CELL (2004)
Tumorigenesis and the angiogenic switch
G Bergers et al.
NATURE REVIEWS CANCER (2003)
GLUT-1 and CAIX as intrinsic markers of hypoxia in carcinoma of the cervix: Relationship to pimonidazole binding
RE Airley et al.
INTERNATIONAL JOURNAL OF CANCER (2003)
The von Hippel-Lindau tumor suppressor, hypoxia-inducible factor-1 (HIF-1) degradation, and cancer pathogenesis
CW Pugh et al.
SEMINARS IN CANCER BIOLOGY (2003)
Expression of hypoxia-inducible factor-1α in cervical carcinomas:: Correlation with tumor oxygenation
HK Haugland et al.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS (2002)
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor
H Yoshida et al.
CELL (2001)
A conserved family of prolyl-4-hydroxylases that modify HIF
RK Bruick et al.
SCIENCE (2001)
C-elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
ACR Epstein et al.
CELL (2001)
HIFα targeted for VHL-mediated destruction by proline hydroxylation:: Implications for O2 sensing
M Ivan et al.
SCIENCE (2001)
Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
P Jaakkola et al.
SCIENCE (2001)
Tumor hypoxia:: Definitions and current clinical, biologic, and molecular aspects
M Höckel et al.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE (2001)
Hypoxia inducible factor-α binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
ME Cockman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
GL Semenza
JOURNAL OF APPLIED PHYSIOLOGY (2000)
分享论文
