期刊
ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES
卷 15, 期 6, 页码 685-700出版社
SHENYANG PHARMACEUTICAL UNIV
DOI: 10.1016/j.ajps.2020.03.001
关键词
Ursolic acid; Nanosytems; Carrier-free; Photosensitizer; Anticancer
资金
- National Natural Science Foundation of China [81972832, 81472767]
- Scientific Research Training Program for Undergraduate of Fuzhou University [25055, 25068]
Ursolic acid (UA), a natural pentacyclic triterpenoid, possesses widespread biological and pharmacological activities. However, drawbacks such as low bioavailability, poor targeting and rapid metabolism greatly hinder its further clinical application. Recently, with the development of nanotechnology, various UA nanosystems have emerged as promising strategies for effective cancer therapy. This article reviews various types of UA-based nano-delivery systems, primarily with emphasis placed on novel UA-based carrier-free nano-drugs, which are considered to be innovative methods for cancer therapy. Moreover, this review presents carrier-free nano-drugs that co-assembled of UA and photosensitizers that displayed synergistic antitumor performance. Finally, the article also describes the development and challenges of UA nanosystems for future research in this field. Overall, the information presented in this review will provide new insight into the rational utilization of nano-drugs in cancer therapy. (c) 2020 Shenyang Pharmaceutical University. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license. (http://creativecommons.org/licenses/by-nc-nd/4.0/)
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