期刊
ADVANCED MATERIALS TECHNOLOGIES
卷 5, 期 8, 页码 -出版社
WILEY
DOI: 10.1002/admt.201901044
关键词
bioinks; biomimetic materials; bioprinting; microfluidics; tissue engineering
资金
- National Institutes of Health [EB021857-01A1, AR073135]
- Department of Defense: BiofabUSA Quick Start Project
- Natural Sciences and Engineering Research Council of Canada [NSERC: 50503-10243]
- Federal Economic Development Agency for Southern Ontario (FedDev Ontario) [809104]
- National Science Centre -Poland (NCN) within the POLONEZ 3 fellowship - European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant [2016/23/P/NZ1/03604, 665778]
- National Centre for Research and Development [STRATEGMED3/305813/2/NCBR/2017-BIONIC]
- Natural Science and Engineering Research Council of Canada
- Canada Research Chairs program
- Michael Smith Foundation for Health Research
- Pacific Parkinson's Research Institute
Next generation engineered tissue constructs with complex and ordered architectures aim to better mimic the native tissue structures, largely due to advances in 3D bioprinting techniques. Extrusion bioprinting has drawn tremendous attention due to its widespread availability, cost-effectiveness, simplicity, and its facile and rapid processing. However, poor printing resolution and low speed have limited its fidelity and clinical implementation. To circumvent the downsides associated with extrusion printing, microfluidic technologies are increasingly being implemented in 3D bioprinting for engineering living constructs. These technologies enable biofabrication of heterogeneous biomimetic structures made of different types of cells, biomaterials, and biomolecules. Microfluiding bioprinting technology enables highly controlled fabrication of 3D constructs in high resolutions and it has been shown to be useful for building tubular structures and vascularized constructs, which may promote the survival and integration of implanted engineered tissues. Although this field is currently in its early development and the number of bioprinted implants is limited, it is envisioned that it will have a major impact on the production of customized clinical-grade tissue constructs. Further studies are, however, needed to fully demonstrate the effectiveness of the technology in the lab and its translation to the clinic.
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