期刊
CELLS
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cells9051294
关键词
HEV; host factor; particle production; viral replication; virus entry
类别
资金
- Swiss National Science Foundation [31003A_179424, CRSK-3_190706]
- Novartis Foundation [18C140]
- Gilead Sciences International Research Scholars Program in Liver Disease
- Swiss National Science Foundation (SNF) [31003A_179424, CRSK-3_190706] Funding Source: Swiss National Science Foundation (SNF)
Hepatitis E virus (HEV) infection is one of the most common causes of acute hepatitis in the world. HEV is an enterically transmitted positive-strand RNA virus found as a non-enveloped particle in bile as well as stool and as a quasi-enveloped particle in blood. Current understanding of the molecular mechanisms and host factors involved in productive HEV infection is incomplete, but recently developed model systems have facilitated rapid progress in this area. Here, we provide an overview of the HEV life cycle with a focus on the host factors required for viral entry, RNA replication, assembly and release. Further developments of HEV model systems and novel technologies should yield a broader picture in the future.
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