期刊
CELLS
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/cells9051289
关键词
Melanoma; zebrafish; melanocytes; modeling; genetics; microenvironment; xenografts
类别
资金
- NIH [AR063850, CA228120]
- [T32 CA130807]
- [NIH AR063850]
Melanoma is the deadliest form of skin cancer and one of few cancers with a growing incidence. A thorough understanding of its pathogenesis is fundamental to developing new strategies to combat mortality and morbidity. Zebrafish-due in large part to their tractable genetics, conserved pathways, and optical properties-have emerged as an excellent system to model melanoma. Zebrafish have been used to study melanoma from a single tumor initiating cell, through metastasis, remission, and finally into relapse. In this review, we examine seminal zebrafish studies that have advanced our understanding of melanoma.
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