期刊
CELLS
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/cells9040878
关键词
DNA modifications; DNA methylation readers; higher order chromatin structure; heterochromatin; MeCP2; Rett syndrome
类别
资金
- German Research Foundation (DFG) [CA 198/10-1, 16-1]
- China Scholarship Council
Methyl-CpG binding protein 2 (MeCP2) is a multifunctional epigenetic reader playing a role in transcriptional regulation and chromatin structure, which was linked to Rett syndrome in humans. Here, we focus on its isoforms and functional domains, interactions, modifications and mutations found in Rett patients. Finally, we address how these properties regulate and mediate the ability of MeCP2 to orchestrate chromatin compartmentalization and higher order genome architecture.
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