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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Mitochondria in cancer: at the crossroads of life and death
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Chinese Journal of Cancer (2011)
Hypoxia and mitochondrial oxidative metabolism
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)
The electron transfer flavoprotein Ubiquinone oxidoreductases
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2010)
Tumor heterogeneity: Causes and consequences
Andriy Marusyk et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2010)
Glutaminolysis Supplying carbon or nitrogen or both for cancer cells?
Chi V. Dang
CELL CYCLE (2010)
TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1α Stabilization
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CLINICAL CANCER RESEARCH (2010)
TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle
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DIABETES (2010)
The causes of cancer revisited: Mitochondrial malignancy and ROS-induced oncogenic transformation - Why mitochondria are targets for cancer therapy
Stephen J. Ralph et al.
MOLECULAR ASPECTS OF MEDICINE (2010)
Oncogenic KRAS modulates mitochondrial metabolism in human colon cancer cells by inducing HIF-1α and HIF-2α target genes
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MOLECULAR CANCER (2010)
LKB1 and AMP-activated protein kinase control of mTOR signalling and growth
R. J. Shaw
ACTA PHYSIOLOGICA (2009)
Mitochondrial Metabolism and Cancer
Frank Weinberg et al.
HYPOXIA AND CONSEQUENCES FROM MOLECULE TO MALADY (2009)
How mitochondria produce reactive oxygen species
Michael P. Murphy
BIOCHEMICAL JOURNAL (2009)
The mitochondrial p53 pathway
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BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS (2009)
Hypoxia-Inducible Carbonic Anhydrase IX and XII Promote Tumor Cell Growth by Counteracting Acidosis through the Regulation of the Intracellular pH
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CANCER RESEARCH (2009)
Novel Lipogenic Enzyme ELOVL7 Is Involved in Prostate Cancer Growth through Saturated Long-Chain Fatty Acid Metabolism
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CANCER RESEARCH (2009)
Cell-cell and intracellular lactate shuttles
George A. Brooks
JOURNAL OF PHYSIOLOGY-LONDON (2009)
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
Jihye Yun et al.
SCIENCE (2009)
ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
Kathryn E. Wellen et al.
SCIENCE (2009)
The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
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BIOCHEMICAL JOURNAL (2008)
Induction of HIF-1 alpha Expression by Intermittent Hypoxia: Involvement of NADPH Oxidase, Ca2+ Signaling, Prolyl Hydroxylases, and mTOR
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JOURNAL OF CELLULAR PHYSIOLOGY (2008)
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
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JOURNAL OF CLINICAL INVESTIGATION (2008)
Tumour glycolysis: The many faces of HIF
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JOURNAL OF THEORETICAL BIOLOGY (2008)
Ras oncogenes: split personalities
Antoine E. Karnoub et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
PHDs overactivation during chronic hypoxia desensitizes HIFα and protects cells from necrosis
Amandine Ginouves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Hypoxic status in ovarian serous and mucinous tumors:: relationship between histological characteristics and HIF-1α/GLUT-1 expression
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ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2008)
Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
Javier A. Menendez et al.
NATURE REVIEWS CANCER (2007)
A pivotal role for p53: balancing aerobic respiration and glycolysis
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JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2007)
The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology
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PHYSIOLOGICAL REVIEWS (2007)
Clinicopathological significance and linkage of the distribution of HIF-1 alpha and GLUT-1 in human primary colorectal cancer
Andrzej Wincewicz et al.
PATHOLOGY & ONCOLOGY RESEARCH (2007)
Hypoxia-inducible factor-1 (HIF-1)
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MOLECULAR PHARMACOLOGY (2006)
Structure of electron transfer flavoprotein-ubiquinone oxidoreductase and electron transfer to the mitochondrial ubiquinone pool
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Oxidative metabolism in cancer growth
Michael Ristow
CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE (2006)
Ras, PI(3)K and mTOR signalling controls tumour cell growth
Reuben J. Shaw et al.
NATURE (2006)
Regulation of acetyl-CoA carboxylase
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BIOCHEMICAL SOCIETY TRANSACTIONS (2006)
Hypoxic regulation of PFYFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFYFB genes in gastric cancers
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ACTA BIOCHIMICA POLONICA (2006)
Alpha-ketoglutarate dehydrogenase: a target and generator of oxidative stress
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PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES (2005)
Acetyl-coenzyme A carboxylase: crucial metabolic enzyme and attractive target for drug discovery
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CELLULAR AND MOLECULAR LIFE SCIENCES (2005)
Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing
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CELL METABOLISM (2005)
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The glucose transporter families SGLT and GLUT:: Molecular basis of normal and aberrant function.
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JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2004)
Hexokinase II and VEGF expression in liver tumors: correlation with hypoxia-inducible factor-1 alpha and its significance
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JOURNAL OF HEPATOLOGY (2004)
TSC2 mediates cellular energy response to control cell growth and survival
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CELL (2003)
MO25α/β interact with STRADα/β enhancing their ability to bind, activate and localize LKB1 in the cytoplasm
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EMBO JOURNAL (2003)
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
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EMBO JOURNAL (2003)
Expression of hypoxia-inducible factor-lα is associated with tumor vascularization in human colorectal carcinoma
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INTERNATIONAL JOURNAL OF CANCER (2003)
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
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GENES & DEVELOPMENT (2002)
Regulation of an activated S6 kinase 1 variant reveals a novel mammalian target of rapamycin phosphorylation site
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JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Activation of the HIF pathway in cancer
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CURRENT OPINION IN GENETICS & DEVELOPMENT (2001)