期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 4, 页码 -出版社
MDPI
DOI: 10.3390/jcm9041126
关键词
COVID-19; 2019-nCoV; SARS-CoV-2; oral cavity; mouthrinse; beta-cyclodextrins; Citrox; viral load; microbiome
Considered to be a major portal of entry for infectious agents, the oral cavity is directly associated with the evolutionary process of SARS-CoV-2 in its inhalation of ambient particles in the air and in expectorations. Some new generations of mouth rinses currently on the market have ingredients that could contribute to lower the SARS-CoV-2 viral load, and thus facilitate the fight against oral transmission. If chlorhexidine, a usual component of mouth rinse, is not efficient to kill SARS-CoV-2, the use of a mouth rinses and/or with local nasal applications that contain beta-cyclodextrins combined with flavonoids agents, such as Citrox, could provide valuable adjunctive treatment to reduce the viral load of saliva and nasopharyngeal microbiota, including potential SARS-CoV-2 carriage. We urge national agencies and authorities to start clinical trials to evaluate the preventive effects of beta CD-Citrox therapeutic oral biofilm rinses in reducing the viral load of the infection and possibly disease progression.
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