期刊
JOURNAL OF CLINICAL MEDICINE
卷 9, 期 5, 页码 -出版社
MDPI
DOI: 10.3390/jcm9051417
关键词
ACE2; acute kidney injury; blood pressure; catepsin; coronavirus; COVID; cytokine storm; endothelium; heparin; Kawasaki disease
资金
- NIH [R01-DK123259, R01-HL146691, R01-DK033823, R00-DK107895]
- American Heart Association [AHA-20POST35211151]
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.
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