期刊
JOURNAL FOR IMMUNOTHERAPY OF CANCER
卷 8, 期 1, 页码 -出版社
BMJ PUBLISHING GROUP
DOI: 10.1136/jitc-2019-000337
关键词
oncology; immunology; molecular biology
资金
- US Department of Defense (DoD)
- Breast Cancer Research Program (BRCP) [BC180476P1]
- Dept. of Radiation Oncology at Weill Cornell Medicine
- Associazione Italiana per la Ricerca sul Cancro (AIRC, IG)) [20417]
- Italian Institute for Genomic Medicine (Candiolo, Turin, Italy)
- Compagnia di San Paolo (Turin, Italy)
Cells succumbing to stress via regulated cell death (RCD) can initiate an adaptive immune response associated with immunological memory, provided they display sufficient antigenicity and adjuvanticity. Moreover, multiple intracellular and microenvironmental features determine the propensity of RCD to drive adaptive immunity. Here, we provide an updated operational definition of immunogenic cell death (ICD), discuss the key factors that dictate the ability of dying cells to drive an adaptive immune response, summarize experimental assays that are currently available for the assessment of ICD in vitro and in vivo, and formulate guidelines for their interpretation.
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