期刊
SCIENCE ADVANCES
卷 6, 期 13, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aay7608
关键词
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资金
- National Natural Science Foundation of China [31430029, 81471792, 31870960]
- National Key RD Project [2018YFC1105701]
- UK Regenerative Medicine Platform Acellular Approaches for Therapeutic Delivery [MR/K026682/1]
- UK Regenerative Medicine Platform A Hub for Engineering and Exploiting the Stem Cell Niche [MR/K026666/1]
- MRC [MR/R015651/1, MR/K026666/1, MR/K026682/1] Funding Source: UKRI
Cellular bioenergetics (CBE) plays a critical role in tissue regeneration. Physiologically, an enhanced metabolic state facilitates anabolic biosynthesis and mitosis to accelerate regeneration. However, the development of approaches to reprogram CBE, toward the treatment of substantial tissue injuries, has been limited thus far. Here, we show that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold compared to commercialized poly(lactic acid) and calcium phosphate ceramic scaffolds. This material was composed of energy-active units that can be released in a sustained degradation-mediated fashion once implanted. By establishing an intramitochondrial metabolic bypass, the internalized energy-active units significantly elevate mitochondrial membrane potential (Delta Psi m) to supply increased bioenergetic levels and accelerate bone formation. The ready-to-use material developed here represents a highly efficient and easy-to-implement therapeutic approach toward tissue regeneration, with promise for benchto-bedside translation.
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