期刊
SCIENCE ADVANCES
卷 6, 期 12, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aay2789
关键词
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资金
- NIH BRAIN Initiative grant [U01NS094248]
- NIH [R21NS104861]
- NIH SBIR grant [5R43MH110287]
- DARPA's NESD program [N66001-17-C-4005]
- GG Technologies gift fund
- Wu Tsai Institute Big Ideas program
- NSF [GRFP DGE-114747]
- NSF IGERT grant [0801700]
- Francis Crick Institute from Cancer Research UK [FC001153]
- Francis Crick Institute from UK Medical Research Council [FC001153]
- Francis Crick Institute from Wellcome Trust [FC001153]
- HFSP grant [RGP 00048/2013]
- Medical Research Council [MC_UP_1202/5]
- European Union through the H2020 ERC Advanced Grant neuroXscales [694829]
- Swiss National Science Foundation Ambizione grant [PZ00P3-167989]
- MRC [MC_UP_1202/5] Funding Source: UKRI
- Swiss National Science Foundation (SNF) [PZ00P3_167989] Funding Source: Swiss National Science Foundation (SNF)
Multi-channel electrical recordings of neural activity in the brain is an increasingly powerful method revealing new aspects of neural communication, computation, and prosthetics. However, while planar silicon-based CMOS devices in conventional electronics scale rapidly, neural interface devices have not kept pace. Here, we present a new strategy to interface silicon-based chips with three-dimensional microwire arrays, providing the link between rapidly-developing electronics and high density neural interfaces. The system consists of a bundle of microwires mated to large-scale microelectrode arrays, such as camera chips. This system has excellent recording performance, demonstrated via single unit and local-field potential recordings in isolated retina and in the motor cortex or striatum of awake moving mice. The modular design enables a variety of microwire types and sizes to be integrated with different types of pixel arrays, connecting the rapid progress of commercial multiplexing, digitisation and data acquisition hardware together with a three-dimensional neural interface.
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