期刊
CHEMISTRYSELECT
卷 5, 期 20, 页码 5939-5958出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.201904844
关键词
Cyclomatrix polyphosphazene based micro; nanospheres; Drug release; Preparation
Polyphosphazenes (PPZs) are the hybrid polymers composed of nitrogen and phosphorous atoms linked through alternate single and double bond. For the preparation of cyclomatrix polyphosphazene (CMPPZ) based micro/nanospheres, hexachlorocyclotriphosphazene (HCCP) was reacted with monomers containing hydroxyl and amino groups. The cross-linked structure of CMPPZ is biodegradable and biocompatible in nature. The CMPPZ based micro/nanospheres have potential application in the field of biomedical. In this review article, we have described the different ways for the preparation of CMPPZ based micro/nanospheres and their drug release behavior. The average diameter size and surface morphology of the highly cross-linked CMPPZ based micro/nanospheres depended on the concentration of both the monomers. This review article also emphasized on the drug release properties of the CMPPZ based micro/nanospheres.
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