Recent Progress on the Preparation of Cyclomatrix-Polyphosphazene Based Micro/Nanospheres and Their Application for Drug Release

Polyphosphazenes (PPZs) are the hybrid polymers composed of nitrogen and phosphorous atoms linked through alternate single and double bond. For the preparation of cyclomatrix polyphosphazene (CMPPZ) based micro/nanospheres, hexachlorocyclotriphosphazene (HCCP) was reacted with monomers containing hydroxyl and amino groups. The cross-linked structure of CMPPZ is biodegradable and biocompatible in nature. The CMPPZ based micro/nanospheres have potential application in the field of biomedical. In this review article, we have described the different ways for the preparation of CMPPZ based micro/nanospheres and their drug release behavior. The average diameter size and surface morphology of the highly cross-linked CMPPZ based micro/nanospheres depended on the concentration of both the monomers. This review article also emphasized on the drug release properties of the CMPPZ based micro/nanospheres.