The Dotz Benzannulation Reaction: A Booming Methodology for Natural Product Synthesis

Since its finding in 1975, the Dotz benzannulation reaction has attracted a great attention of the scientific community as it permits the regio-controlled construction of functionalised aromatic frameworks from acyclic precursors. In recent years, this beautifully simple yet much powerful technique for the formation of C-C bonds has opened-up new possibilities in modern synthetic organic chemistry. In this Review, we report the developments in natural products synthesis by employing the Dotz benzannulation as a key transformation. Although, a flow of publications have witnessed a constant progress in this wonderful area of research, but to our best knowledge this is the first review which purely focuses on the applications of the Dotz benzannulation reaction in natural product synthesis. We are assured that this review will act as a promoter in amplifying the applications of the Dotz benzannulation in the domain of synthetic organic chemistry.